Accuracy profiles assessing the validity for routine use of high-performance thin-layer chromatographic assays for drug formulations

Last updated on 22-8-2019 by Anonymous (not verified)

Public Access


Peer reviewed scientific article


The accuracy profile, based on total error, integrates several validation parameters, such as trueness, precision and linearity, providing one statistic which enables decision on the suitability of a method for its intended purpose. Two assay methods for formulations are validated using accuracy profiles as an alternative approach to classic method validation. It concerns high-performance thin-layer chromatography (HPTLC) methods, which initially were validated using the classic approach. The first method assayed sulfamethoxazole and trimethoprim, and the second lamivudine, stavudine and ne…

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