Clonal Spread of Candida glabrata Bloodstream Isolates and Fluconazole Resistance Affected by Prolonged Exposure: a 12-Year Single-Center Study in Belgium.

Last updated on 22-8-2019 by Anonymous (not verified)

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Peer reviewed scientific article



is a major cause of candidemia in immunocompromised patients and is characterized by a high-level of fluconazole resistance. In the present study, the acquisition of antifungal resistance and potential clonal spread of were explored at a single center over a 12-year period by analyzing 187 independent clinical bloodstream isolates. One strain was found to be micafungin resistant due to a mutation in the gene. Fluconazole resistance remained stable throughout the period and was observed in 20 (10.7%) of the isolates. An analysis of the antifungal consumption data revealed that recent prior e…

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