Last updated on 22-8-2019 by Anonymous (not verified)
Peer reviewed scientific article
SCIENSANO
Authors
Renson, P; Le Dimna, M; Gabriel, C; Levai, R; Blome, S; Kulcsar, G; F. Koenen; Le Potier, M FKeywords
Abstract:
CP7_E2alf is a promising marker vaccine candidate against classical swine fever (CSF). To better understand the mechanisms of protection, cytokine and isotype-specific antibody profiles were investigated in CP7_E2alf vaccinated pigs before and after challenge with the highly virulent CSFV strain “Koslov” at 14 days or 6 months post-vaccination. The interference of vaccination with CSFV pathogeny-related cytokine responses, previously described following a moderately virulent challenge, was confirmed. However, the levels of additional cytokines, TNF-α and IL-6, were significantly attenuated …