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  3. Design and evaluation of analogues of the bacterial cell-wall peptidoglycan motif L-Lys-D-Ala-D-Ala for use in a vancomycin biosensor93

Design and evaluation of analogues of the bacterial cell-wall peptidoglycan motif L-Lys-D-Ala-D-Ala for use in a vancomycin biosensor93

Last updated on 22-8-2019 by Anonymous (not verified)

Public Access

Published

Peer reviewed scientific article

DOI : http://dx.doi.org/10.1016/j.bmcl.2007.08.055

Authors

Hernout,O.; Berthoin,K.; I. Delattre; Tulkens,P.M.; Carryn,S.; Marchand-Brynaert,J.

Keywords

  1. 0
  2. a
  3. an
  4. analysis
  5. approach
  6. approaches
  7. article
  8. bacteria
  9. Belgium
  10. Biosensing Techniques
  11. Cell Wall
  12. chemistry
  13. Chimie
  14. Chromatography,High Pressure Liquid
  15. competition
  16. de
  17. Design
  18. detection
  19. Drug Design
  20. Drug Evaluation,Preclinical
  21. ET
  22. EVALUATION
  23. im
  24. IS
  25. journal
  26. Molecular
  27. MS
  28. ON
  29. Peptidoglycan
  30. Print
  31. Receptor
  32. receptors
  33. Research
  34. Research Support
  35. SB - IM
  36. Spectrophotometry,Ultraviolet
  37. Spectroscopy,Fourier Transform Infrared
  38. Target
  39. use
  40. values
  41. Vancomycin

Abstract:

Four small molecular receptors of vancomycin have been designed to make part of a novel biosensor device based on the FTIR-ATR detection: N-Boc (2a) or N-Ac (2b)-6-aminocaproyl-D-Ala-D-Ala and N-Boc (3a) or N-Ac (3b)-6-aminocaproyl-D-Ala-d-Ser. Using an original microbiological approach to assess the competition of compounds with the natural target of vancomycin in bacteria, EC(50) values of 6.3-8.0 x 10(-5)M (2a-b) and 7.1-9.3 x 10(-4)M (3a-b) were determined. Vancomycin:2b complex was characterized by MS
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