Last updated on 22-8-2019 by Anonymous (not verified)
Peer reviewed scientific article
AuthorsUlmer, J B; Montgomery, D L; Tang, A; Zhu, L; Deck, R R; C DeWitt; Olivier J Denis; I Orme; Content, J; Huygen, K
DNA plasmids encoding Mycobacterium tuberculosis antigen 85 (Ag85) were tested as vaccines in animal models. Ag85 DNA induced relevant immune responses (i.e. T helper (Th) cells, Th1 cytokines and cytotoxic T lymphocytes) and was protective in mouse and guinea pig models of mycobacterial disease. Therefore, DNA vaccination holds promise as an effective means of preventing tuberculosis in humans. Furthermore, this technique is amenable to identifying the protective antigens of M. tuberculosis.