TY - JOUR T1 - Soluble transferrin receptor level: a new marker of iron deficiency anemia, a common manifestation of gastric autoimmunity in type 1 diabetes24 JF - Diabetes Care Y1 - 2000 A1 - De Block,C.E. A1 - C . Van Campenhout A1 - Ilse De Leeuw A1 - B. Keenoy A1 - Martin,M. A1 - V. Van Hoof A1 - L. Van Gaal KW - 0 KW - a KW - Adult KW - age KW - analysi KW - analysis KW - ANEMIA KW - Anemia,Iron-Deficiency KW - antibodies KW - Antibody KW - Antwerp KW - article KW - at KW - Autoantibodies KW - Autoimmunity KW - Belgium KW - Biological Markers KW - blood KW - Cell KW - Common KW - complications KW - Control KW - Deficiency KW - Design KW - developing KW - diabete KW - diabetes KW - Diabetes Mellitus,Type 1 KW - diabetic KW - Diagnosis KW - Etiology KW - factors KW - Faculty KW - Female KW - Ferritin KW - Gastritis KW - Gastritis,Atrophic KW - Hemoglobin KW - Hemoglobin A,Glycosylated KW - hormonal KW - hospital KW - Humans KW - Hypothesis KW - im KW - immunology KW - Indicator KW - Individuals KW - Inflammation KW - Iron KW - IS KW - journal KW - LEVEL KW - levels KW - Liver KW - Male KW - Marker KW - Markers KW - measure KW - measures KW - Medicine KW - MEN KW - method KW - methods KW - Objective KW - ODDS RATIO KW - outcome KW - p KW - Parietal Cells,Gastric KW - Patient KW - patients KW - present KW - Print KW - Ratio KW - Receptor KW - receptors KW - Receptors,Transferrin KW - regression KW - regression analysis KW - Research KW - Research Design KW - result KW - results KW - risk KW - Risk factor KW - Risk Factors KW - Risk-factor KW - Risk-factors KW - Roc Curve KW - SB - IM KW - Sensitivity and Specificity KW - sex KW - status KW - Transferrin KW - Type KW - Universities KW - university KW - university hospital KW - WHO KW - WOMEN AB - OBJECTIVE: A total of 15-20% of type 1 diabetic patients have parietal cell antibodies (PCAs). PCA+ subjects are at increased risk for iron deficiency anemia and atrophic gastritis. Recently, soluble transferrin receptor (sTfR) levels have proven to be a sensitive indicator for iron deficiency They are, in contrast with ferritin levels, independent of inflammation, liver and hormonal status, and sex. We are the first to evaluate sTfR levels in type 1 diabetes and tested the hypothesis of higher sTfR levels in patients with PCAs and/or autoimmune gastritis. RESEARCH DESIGN AND METHODS: We examined 148 type 1 diabetic patients (85 men and 63 women; 50 were PCA+) and 59 sex- and age-matched control subjects (30 men and 29 women). The main outcome measures were sTfR levels, iron deficiency anemia, and atrophic gastritis. Logistical regression analysis tested risk factors for iron deficiency RESULTS: Iron deficiency was present in 38 subjects. Iron (P<0.0001) and ferritin (P<0.0001) levels but not sTfR levels were lower in women. sTfR levels were similar in diabetic and control subjects but were higher in PCA+ subjects (P = 0.015). In diabetic subjects, iron deficiency anemia was more prevalent in PCA+ than in PCA- patients (odds ratio 3.07, P = 0.013) and was associated with sex (P = 0.0001), age (P = 0.046), and sTfR (P = 0.0008) levels. Atrophic gastritis was present in 15 of 28 PCA+ and in 1 of 11 PCA diabetic subjects (P = 0.014). sTfR levels tended to be higher in patients with atrophic gastritis (P = 0.062). CONCLUSIONS: In type 1 diabetes, sTfR levels can be used to diagnose iron deficiency anemia, which is more prevalent in PCA+ subjects. sTfR levels are higher in PCA+ individuals who are at risk for developing atrophic gastritis VL - 23 CP - 9 U1 - 38631 ER -