TY - JOUR T1 - Susceptibility of Gardnerella vaginalis to thiamphenicol: clinical experience with nonspecific vaginitis JF - Sex Transm.Dis. Y1 - 1984 A1 - Hubrechts,J.M. A1 - R. Vanhoof A1 - Daems,A. A1 - Butzler,J.P. KW - 0 KW - Activity KW - Agent KW - Agents KW - ALL KW - an KW - Anti-Bacterial Agents KW - Antibiotic KW - antibiotics KW - Antimicrobial KW - article KW - at KW - Case KW - Chloramphenicol KW - Clindamycin KW - Clinical KW - Comparative Study KW - drug effects KW - drug therapy KW - Erythromycin KW - Etiology KW - Experience KW - Female KW - Follow up KW - FOLLOW-UP KW - Gardnerella vaginalis KW - Haemophilus KW - Haemophilus Infections KW - Humans KW - im KW - Injections,Intramuscular KW - invitro KW - IS KW - journal KW - Metronidazole KW - Microbial Sensitivity Tests KW - observed KW - pharmacology KW - Print KW - result KW - results KW - SB - IM KW - strain KW - study KW - Tetracycline KW - therapeutic use KW - Thiamphenicol KW - treatment KW - Vaginitis KW - Volunteers AB - We compared the in-vitro activity of thiamphenicol against 100 strains of Gardnerella vaginalis with the activity of 11 other antimicrobial agents. The MICs for thiamphenicol ranged from 0.39 micrograms/ml to 6.25 micrograms/ml. The concentration at which 50% of strains were inhibited (MIC50) was 1.96 micrograms/ml, and the concentration at which 90% of strains were inhibited (MIC90) was 3.93 micrograms/ml. All strains were very susceptible to erythromycin, chloramphenicol, beta-lactam antibiotics, and clindamycin. Tetracycline and metronidazole were only moderately active. In an attempt to cure G. vaginalis-associated vaginitis with a single-dose treatment, we administered 2.25 g of thiamphenicol to 20 volunteers; 17 were clinically and bacteriologically cured. In two cases we observed that G. vaginalis was not eliminated immediately (i.e., at the first follow-up visit), but we saw a progressive disappearance of the strain without further treatment. In one case the treatment seemed to have failed but reinfection could not be ruled out. The results show that a single dose of thiamphenicol can cure G. vaginalis-associated vaginitis VL - 11 CP - 4 Suppl U1 - 37316 ER -