TY - JOUR T1 - Neuroendocrinological and molecular aspects of insect reproduction4406 JF - J.Neuroendocrinol. Y1 - 2004 A1 - Simonet,G. A1 - J Poels A1 - Claeys,I. A1 - T. Van Loy A1 - Franssens,V. A1 - A. De Loof A1 - J. Vanden Broeck KW - 0 KW - a KW - additional KW - Adult KW - an KW - Animal KW - Animals KW - Area KW - article KW - AS KW - aspects KW - Belgium KW - biosynthesis KW - concept KW - concepts KW - Control KW - data KW - Ecdysteroids KW - Enzymes KW - factors KW - Functional KW - future KW - genomic KW - Genomics KW - Gonads KW - growth KW - Hormone KW - hormones KW - im KW - Insect Hormones KW - Insects KW - Institute KW - IS KW - journal KW - Juvenile Hormones KW - Laboratories KW - LEVEL KW - Molecular KW - Neuropeptides KW - Neurosecretory Systems KW - ON KW - Pathways KW - Peptides KW - physiology KW - Print KW - PROCESSES KW - prospects KW - Proteomics KW - Receptor KW - receptors KW - regulation KW - reproduction KW - reproductive physiology KW - Research KW - Research Support KW - response KW - result KW - REVIEW KW - Role KW - SB - IM KW - Sexual Behavior,Animal KW - Signal Transduction KW - Species KW - study KW - Tissue KW - Transcription Factors KW - varieties KW - variety AB - This review summarizes recent advances and novel concepts in the area of insect reproductive neuroendocrinology. The role of 'classic' hormones, such as ecdysteroids and juvenoids, to control reproduction is well documented in a large variety of insect species. In adult gonads, ecdysteroids appear to induce a cascade of transcription factors, many of which also occur during the larval molting response. Recent molecular and functional data have created opportunities to study an additional level of regulation, that of neuropeptides, growth factors and their respective receptors. As a result, many homologs of factors playing a role in vertebrate reproductive physiology have been discovered in insects. This review highlights several neuropeptides controlling the biosynthesis and release of the 'classic' insect hormones, as well as various peptides and biogenic amines that regulate behavioural aspects of the reproduction process. In addition, hormone metabolizing enzymes and second messenger pathways are discussed with respect to their role in reproductive tissues. Finally, we speculate on future prospects for insect neuroendocrinological research as a consequence of the recent 'Genomics Revolution' VL - 16 CP - 8 U1 - 4406 M3 - 10.1111/j.1365-2826.2004.01222.x [doi];JNE1222 [pii] ER -