TY - Generic T1 - Benefits of genomics in the risk assessment of genetically modified plants for human consumption Y1 - 2014 A1 - Willems,S. A1 - Sigrid C.J. De Keersmaecker A1 - Philippe Herman A1 - Nancy Roosens ED - Global Engage KW - a KW - analysi KW - analysis KW - application KW - applications KW - approach KW - approaches KW - Area KW - Areas KW - AS KW - assessment KW - Benefit KW - benefits KW - Combination KW - Congresses KW - CONSUMPTION KW - crops KW - Dna KW - effect KW - effects KW - Europe KW - Genetic KW - genetic modification KW - genetically KW - Genetically modified KW - Genetically modified organism KW - genetically modified plant KW - Genetically modified plants KW - genomic KW - Genomics KW - GMO KW - GMOs KW - Human KW - identification KW - Impact KW - IS KW - Molecular KW - Molecular Characterisation KW - Next-generation sequencing KW - NGS KW - ON KW - PCR KW - plant KW - Plants KW - polymerase chain reaction KW - Project KW - RANGE KW - region KW - Regulatory KW - Research KW - result KW - risk KW - Risk Assessment KW - SAFETY KW - Safety assessment KW - STANDARD KW - Transgenic KW - unintended effects KW - use AB - Within the Genetically Modified Organism (GMO) regulatory framework, the safety assessment of GMOs involves the identification of the intended and unintended effects as a result of the genetic modification, a.o. through molecular characterisation. For most of the current transgenic crops the molecular characterisation consists of the determination of inserted DNA including the insert sequence, the insertion site(s), the number of inserts and its/their flanking regions. This is currently typically done by Southern blot (SB) and Polymerase chain reaction (PCR) analysis in combination with standard sequencing approaches. Next-generation sequencing (NGS) has had a profound impact on several areas of genomic research. Along with the diverse range of applications of NGS, some recent research projects and product developers explored the use of NGS as a tool for the molecular characterisation of GMOs in view of their risk assessment. JF - 2nd Plant Genomics Congress Europe CP - Global Engage U1 - 493 U2 - 12-05-14 to 13-05-14 ER -