TY - JOUR T1 - The VP2 variable region of African and German isolates of infectious bursal disease virus: comparison with very virulent, "classical" virulent, and attenuated tissue culture-adapted strains. JF - Arch Virol Y1 - 2000 A1 - Zierenberg, K A1 - Nieper, H A1 - Thierry van den Berg A1 - Ezeokoli, C D A1 - Voss, M A1 - Müller, H KW - Africa KW - Amino Acid Sequence KW - Amino Acid Substitution KW - Animals KW - Base Sequence KW - Birnaviridae Infections KW - Chickens KW - Disease Outbreaks KW - Genetic Variation KW - Germany KW - Infectious bursal disease virus KW - Molecular Sequence Data KW - Phylogeny KW - Poultry Diseases KW - Sequence Alignment KW - Sequence Analysis, DNA KW - Vaccines, Attenuated KW - Viral Structural Proteins KW - virulence KW - Virus Cultivation AB -

11 African and two German IBDV strains isolated in the mid '80s from field outbreaks in vaccinated and unvaccinated chicken flocks displayed features of very virulent (vv) IBDV strains. The sequence data of the VP2 variable region and phylogenetic analysis confirm that these strains can be grouped within vv IBDV strains which appeared at the same time on the three continents Africa, Asia, and Europe. Strain Cu-1wt, responsible for severe IBD outbreaks in Germany 13 years earlier, showed some relatedness to these strains, but also significant differences at the genomic level, even though this strain has also features of the vv IBDV strains.

VL - 145 CP - 1 U1 - http://www.ncbi.nlm.nih.gov/pubmed/10664410?dopt=Abstract ER -