TY - JOUR T1 - The Panhandle formed by influenza A and C virus NS non-coding regions determines NS segment expression. JF - PLoS One Y1 - 2013 A1 - Bernadette Crescenzo-Chaigne A1 - Cyril Barbezange A1 - Sylvie van der Werf KW - Humans KW - Influenza A virus KW - Influenzavirus C KW - Viral Nonstructural Proteins AB -

Exchange of the extremities of the NS segment of type A and C influenza viruses in reverse genetics systems was used to assess their putative role in type specificity. Restoration of each specific proximal panhandle was mandatory to allow the rescue of viruses with heterotypic extremities. Moreover, the transcription level of the modified segment seemed to be directly affected by the distal panhandle strength.

VL - 8 CP - 11 M3 - 10.1371/journal.pone.0081550 ER -