TY - Generic T1 - Transitions and trajectories in frailty states over time: a systematic review of the European Joint Action ADVANTAGE. T2 - Ann Ist Super Sanita Y1 - 2018 A1 - Rónán O'Caoimh A1 - Lucia Galluzzo A1 - Ángel Rodríguez-Laso A1 - Johan Van der Heyden A1 - Anette Ranhoff Hylen A1 - Laure Carcaillon-Bentata A1 - Nathalie Beltzer A1 - Siobhán Kennelly A1 - Aaron Liew KW - Adult KW - Aged KW - Aged, 80 and over KW - Disease Progression KW - Europe KW - Female KW - Frail Elderly KW - frailty KW - Humans KW - Longitudinal Studies KW - Male KW - middle aged AB -

INTRODUCTION: Frailty is a dynamic syndrome and may be reversible. Despite this, little is known about trajectories or transitions between different stages of frailty.

METHODS: A systematic review was conducted, selecting studies reporting frailty trajectories or transition states for adults in any settings in European ADVANTAGE Joint Action Member States.

RESULTS: Only three papers were included. Data were from longitudinal community-based cohorts in the United Kingdom, Netherlands and Italy. The English study investigated the effect of physical activity on the progression of frailty over a 10-year period. Two presented data on the proportion of participants experiencing at least one frailty transition over time (32.6% in the Italian sample aged ≥ 65 years followed for 4.4 years; 34.3% in the Dutch sample aged 65-75 years, followed for 2 years).

CONCLUSIONS: Data on frailty trajectories and transition states were limited and heterogeneous. Well-designed prospective studies and harmonized approaches to data collection are now needed.

JF - Ann Ist Super Sanita VL - 54 CP - 3 M3 - 10.4415/ANN_18_03_12 ER -