%0 Journal Article %J Eur.J.Clin.Microbiol.Infect.Dis. %D 2004 %T In vitro activity of amphotericin B, fluconazole and voriconazole against 162 Cryptococcus neoformans isolates from Africa and Cambodia36727 %A Chandenier,J. %A Adou-Bryn,K.D. %A Douchet,C. %A Sar,B. %A Kombila,M. %A Swinne,D. %A Therizol-Ferly,M. %A Buisson,Y. %A Richard-Lenoble,D. %K 0 %K Activity %K Africa %K AFRICAN %K Agent %K Agents %K Amphotericin B %K Antifungal Agents %K Area %K Areas %K article %K Cambodia %K Comparative Study %K Cryptococcosis %K Cryptococcus %K de %K Developing Countries %K Diagnosis %K differences %K drug effects %K Drug Resistance,Fungal %K epidemiology %K ET %K evidence %K Female %K Fluconazole %K France %K Humans %K i %K im %K IS %K isolation & purification %K journal %K Less %K Male %K management %K method %K Microbial Sensitivity Tests %K Order %K pharmacology %K Print %K Pyrimidines %K result %K results %K Risk Assessment %K Role %K Sampling Studies %K SB - IM %K Service %K study %K TESTING %K triazoles %X In order to determine the potential role that various antifungal agents might have in the management of cryptococcosis in tropical areas, the in vitro susceptibility of Cryptococcus neoformans isolates from Africa ( n=52) and Cambodia ( n=110) to three antifungal agents (amphotericin B, fluconazole and voriconazole) were compared using the E-test method. The results of this study (i) confirm the value of the E-test for testing the in vitro susceptibility of C. neoformans towards voriconazole; (ii) provide the first evidence demonstrating good activity of amphotericin B, fluconazole and voriconazole against Cambodian isolates; and (iii) show there are differences in susceptibility between African and Asian C. neoformans isolates, with Cambodian isolates appearing less susceptible to the agents tested but with amphotericin B maintaining good activity %B Eur.J.Clin.Microbiol.Infect.Dis. %V 23 %P 506 - 508 %8 0/6/2004 %G eng %N 6 %1 38117 %& 506 %R http://dx.doi.org/10.1007/s10096-004-1136-2