%0 Generic %D 2012 %T Identification of potential migrants from printing inks used on paper and board food contact materials %A Els Van Hoeck %A Evrard,C. %A N'Goy,T. %A Joris Van Loco %A F. Bolle %K an %K approach %K approaches %K article %K AS %K at %K challenge %K Change %K chromatography %K composition %K conditions %K CONTACT %K contribution %K Development %K EU %K European %K food %K food contact %K food contact material %K Food Packaging %K foodstuffs %K gas chromatography %K Gas Chromatography-Mass Spectrometry %K health %K high resolution mass spectrometry %K Human %K human health %K identification %K identification of unkowns %K identify %K Impact %K INFORMATION %K Instrument %K Instruments %K International %K IS %K liquid chromatography %K Mass %K Mass Spectrometry %K method %K methods %K Migration %K Mode %K ON %K Paper %K pattern %K PATTERNS %K photoinitiators %K Practice %K PRACTICES %K printing ink %K public %K public health %K Public-health %K regulation %K Requirements %K result %K results %K SAFETY %K Sample %K Samples %K SCREENING %K Screening method %K Solvents %K State %K symposium %K Target %K time %K use %K work %X

Printing inks, used on paper and board food packaging, are often fairly complex formulations of colorants, resins, solvents, additives and photoinitiators. Although European legislation does not specifically cover printing inks in their supplied form, there are some legislative instruments which have an impact on materials and articles intended for direct contact with food, such as Article 3 of EU Regulation 1935/2004, that states that materials and articles intended to come into contact with foodstuffs shall not, in accordance with good shall be manufactured in accordance with good manufacturing practices, so that under normal and foreseeable conditions of use, they do not transfer their constituents to foodstuffs in quantities which could endanger human health, or bring about an unacceptable change in the composition of the foodstuffs, or bring about a deterioration in the organoleptic characteristics thereof. Inks, once printed on the non-food-contact side of the packaging has to comply with the requirements of Article 3. Identification of potential migrants from printing ink used on paper and board food packaging material is a significant analytical challenge since the real formulations of printing inks are not known. Furthermore, more than 2000 substances can be used in packaging inks, according to the Swiss Federal Office of Public Health Ordinance (Annex 6 of RS 817.023.21). Consequently, large screening methods are needed to identify the substances used in these complex mixtures of printing inks. In this contribution, a method for the identification of potential migrants from printing inks used on paper and board food contact material is presented. The migration experiments were carried out using 1 dm² of a paper or board food packaging, which is cut in little pieces, then 40 mL acetonitrile was added and the migration was performed at 70°C for 24h. Afterwards, the extracts were analysed using gas chromatography-mass spectrometry (GC-MSn) in full scan and liquid chromatography coupled with Time-of-flight mass spectrometry (UPLC-ToF-MS) with both positive and negative electrospray ionization. Two approaches for the identification of unknown substances can be used. One approach is to focus on pre-selected target analytes, with known fragmentation patterns and retention times. In the presented work, a screening method for more then 120 analytes was developed using GC-MS and UPLC-ToF-MS. The substances in this targeted screening method are different additives, resins, solvents and photo-initiators, mentioned in the Swiss Ordinance. The other approach is untargeted screening in full scan mode using high resolution mass spectrometry. Afterwards, the unknown compounds are identified using existing GC-MS libraries, information of the elemental composition and collision induced dissociation (UPLC-ToF-MS). The developed method has already been used for different paper and board samples. The results are shown in this contribution.

%B 5th International symposium on food packaging: Scientific Developments supporting safety and innovation %I NA %C NA %8 0/0/2012 %G eng %N ILSI Europe %1 2043 %2 14-16 november 2012