%0 Journal Article %J Int J Cancer %D 2017 %T Role of mucosal high-risk human papillomavirus types in head and neck cancers in central India. %A Gheit, Tarik %A Anantharaman, Devasena %A Holzinger, Dana %A Alemany, Laia %A Tous, Sara %A Lucas, Eric %A Prabhu, Priya Ramesh %A Pawlita, Michael %A Ridder, Ruediger %A Rehm, Susanne %A Bogers, Johannes %A Maffini, Fausto %A Chiocca, Susanna %A Lloveras, Belén %A Kumar, Rekha Vijay %A Somanathan, Thara %A de Sanjosé, Silvia %A Castellsagué, Xavier %A M. Arbyn %A Brennan, Paul %A Sankaranarayanan, Rengaswamy %A Madhavan R Pillai %A Gangane, Nitin %A Tommasino, Massimo %K Adult %K Aged %K Cyclin-Dependent Kinase Inhibitor p16 %K Female %K Head and Neck Neoplasms %K Humans %K India %K Male %K middle aged %K Papillomaviridae %K Papillomavirus Infections %X

Mucosal high-risk (HR) human papillomaviruses (HPV) cause a subset of head and neck cancers (HNC). The HPV-attributable fraction of HNC varies substantially between countries. Although HNC has a very high incidence in the Indian subcontinent, information on the contribution of HPV infection is limited. Here, we evaluated the HPV-attributable fraction in HNC (N = 364) collected in a central region of India. HNC from three different anatomical subsites were included, namely, oral cavity (n = 252), oropharynx (n = 53) and hypopharynx/larynx (n = 59). In this retrospective study, HPV-driven HNC were defined by presence of both viral DNA and RNA. Overexpression of p16(INK4a) was also evaluated. HR-HPV DNA was detected in 13.7% of the cases; however, only 2.7% were positive for both HPV DNA and RNA. The highest percentage of HPV DNA/RNA double positivity was found in oropharynx (9.4%), followed by larynx (1.7%) and oral cavity (1.6%) (p = 0.02). More than half of HPV DNA/RNA-positive cases were p16(INK4a) -negative, while a considerable number of HPV RNA-negative cases were p16(INK4a) -positive (17.9%). HPV16 was the major type associated with HNC (60.0%), although cases positive for HPV18, 35 and 56 were also detected. Our data indicate that the proportion and types of mucosal HR-HPV associated with HNC in this central Indian region differ from those in other (developed) parts of the world. This may be explained by differences in smoking and/or sexual behaviour compared with North America and northern Europe. Moreover, we show that p16(INK4a) staining appeared not to be a good surrogate marker of HPV transformation in the Indian HNC cases.

%B Int J Cancer %V 141 %P 143-151 %8 2017 Jul 01 %G eng %N 1 %1 http://www.ncbi.nlm.nih.gov/pubmed/28369859?dopt=Abstract %R 10.1002/ijc.30712