%0 Conference Proceedings %B Ann Ist Super Sanita %D 2018 %T Transitions and trajectories in frailty states over time: a systematic review of the European Joint Action ADVANTAGE. %A Rónán O'Caoimh %A Lucia Galluzzo %A Ángel Rodríguez-Laso %A Johan Van der Heyden %A Anette Ranhoff Hylen %A Laure Carcaillon-Bentata %A Nathalie Beltzer %A Siobhán Kennelly %A Aaron Liew %K Adult %K Aged %K Aged, 80 and over %K Disease Progression %K Europe %K Female %K Frail Elderly %K frailty %K Humans %K Longitudinal Studies %K Male %K middle aged %X

INTRODUCTION: Frailty is a dynamic syndrome and may be reversible. Despite this, little is known about trajectories or transitions between different stages of frailty.

METHODS: A systematic review was conducted, selecting studies reporting frailty trajectories or transition states for adults in any settings in European ADVANTAGE Joint Action Member States.

RESULTS: Only three papers were included. Data were from longitudinal community-based cohorts in the United Kingdom, Netherlands and Italy. The English study investigated the effect of physical activity on the progression of frailty over a 10-year period. Two presented data on the proportion of participants experiencing at least one frailty transition over time (32.6% in the Italian sample aged ≥ 65 years followed for 4.4 years; 34.3% in the Dutch sample aged 65-75 years, followed for 2 years).

CONCLUSIONS: Data on frailty trajectories and transition states were limited and heterogeneous. Well-designed prospective studies and harmonized approaches to data collection are now needed.

%B Ann Ist Super Sanita %V 54 %8 2018 Jul-Sep %N 3 %R 10.4415/ANN_18_03_12