<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>46</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Philippe Herman</style></author><author><style face="normal" font="default" size="100%">Verlinden,Y.</style></author><author><style face="normal" font="default" size="100%">Didier Breyer</style></author><author><style face="normal" font="default" size="100%">Van Cleemput,E.</style></author><author><style face="normal" font="default" size="100%">Bernard Brochier</style></author><author><style face="normal" font="default" size="100%">Myriam Sneyers</style></author><author><style face="normal" font="default" size="100%">Snacken,R.</style></author><author><style face="normal" font="default" size="100%">Hermans,P.</style></author><author><style face="normal" font="default" size="100%">Pierre Kerkhofs</style></author><author><style face="normal" font="default" size="100%">Liesnard,C.</style></author><author><style face="normal" font="default" size="100%">Rombaut,B.</style></author><author><style face="normal" font="default" size="100%">Marc Van Ranst</style></author><author><style face="normal" font="default" size="100%">van der Groen,G.</style></author><author><style face="normal" font="default" size="100%">Goubau,P.</style></author><author><style face="normal" font="default" size="100%">William Moens</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Biosafety risk assessment of the Severe Acute Respiratory Syndrome (SARS) coronavirus and containment measures for the diagnostic and research laboratories</style></title><secondary-title><style face="normal" font="default" size="100%">Appl.Biosaf.</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Africa</style></keyword><keyword><style  face="normal" font="default" size="100%">ALL</style></keyword><keyword><style  face="normal" font="default" size="100%">an</style></keyword><keyword><style  face="normal" font="default" size="100%">AS</style></keyword><keyword><style  face="normal" font="default" size="100%">assessment</style></keyword><keyword><style  face="normal" font="default" size="100%">at</style></keyword><keyword><style  face="normal" font="default" size="100%">Belgium</style></keyword><keyword><style  face="normal" font="default" size="100%">biosafety</style></keyword><keyword><style  face="normal" font="default" size="100%">Case</style></keyword><keyword><style  face="normal" font="default" size="100%">containment</style></keyword><keyword><style  face="normal" font="default" size="100%">Control</style></keyword><keyword><style  face="normal" font="default" size="100%">Coronavirus</style></keyword><keyword><style  face="normal" font="default" size="100%">Countries</style></keyword><keyword><style  face="normal" font="default" size="100%">disease</style></keyword><keyword><style  face="normal" font="default" size="100%">environment</style></keyword><keyword><style  face="normal" font="default" size="100%">Europe</style></keyword><keyword><style  face="normal" font="default" size="100%">Guidelines</style></keyword><keyword><style  face="normal" font="default" size="100%">health</style></keyword><keyword><style  face="normal" font="default" size="100%">Human</style></keyword><keyword><style  face="normal" font="default" size="100%">INFECTION</style></keyword><keyword><style  face="normal" font="default" size="100%">International</style></keyword><keyword><style  face="normal" font="default" size="100%">investigation</style></keyword><keyword><style  face="normal" font="default" size="100%">IS</style></keyword><keyword><style  face="normal" font="default" size="100%">Laboratories</style></keyword><keyword><style  face="normal" font="default" size="100%">LEVEL</style></keyword><keyword><style  face="normal" font="default" size="100%">levels</style></keyword><keyword><style  face="normal" font="default" size="100%">measure</style></keyword><keyword><style  face="normal" font="default" size="100%">measures</style></keyword><keyword><style  face="normal" font="default" size="100%">ON</style></keyword><keyword><style  face="normal" font="default" size="100%">Order</style></keyword><keyword><style  face="normal" font="default" size="100%">organization</style></keyword><keyword><style  face="normal" font="default" size="100%">POPULATION</style></keyword><keyword><style  face="normal" font="default" size="100%">Practice</style></keyword><keyword><style  face="normal" font="default" size="100%">PRACTICES</style></keyword><keyword><style  face="normal" font="default" size="100%">production</style></keyword><keyword><style  face="normal" font="default" size="100%">recommendation</style></keyword><keyword><style  face="normal" font="default" size="100%">Recommendations</style></keyword><keyword><style  face="normal" font="default" size="100%">Research</style></keyword><keyword><style  face="normal" font="default" size="100%">Respiratory</style></keyword><keyword><style  face="normal" font="default" size="100%">response</style></keyword><keyword><style  face="normal" font="default" size="100%">risk</style></keyword><keyword><style  face="normal" font="default" size="100%">Risk Assessment</style></keyword><keyword><style  face="normal" font="default" size="100%">SAFETY</style></keyword><keyword><style  face="normal" font="default" size="100%">SARS</style></keyword><keyword><style  face="normal" font="default" size="100%">SBB</style></keyword><keyword><style  face="normal" font="default" size="100%">Spread</style></keyword><keyword><style  face="normal" font="default" size="100%">use</style></keyword><keyword><style  face="normal" font="default" size="100%">VIRUS</style></keyword><keyword><style  face="normal" font="default" size="100%">WHO</style></keyword><keyword><style  face="normal" font="default" size="100%">work</style></keyword><keyword><style  face="normal" font="default" size="100%">world</style></keyword><keyword><style  face="normal" font="default" size="100%">World Health Organization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2004</style></year><pub-dates><date><style  face="normal" font="default" size="100%">0/0/2004</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">142</style></number><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">128 - 142</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">At the end of 2002, an outbreak of a new viral respiratory illness, called SARS (Severe Acute Respiratory Syndrome virus) occurred in China. The disease spread over Asia, North America, Europe and Africa. In response to the SARS outbreak, the World Health Organization (WHO) coordinated an international collaboration that included clinical, epidemiologic and laboratory investigations, and initiated efforts to control the spread of SARS. As in other countries it has been decided to establish biosafety guidelines and recommendations in Belgium with particular emphasis on handling clinical specimens associated with SARS for research, production and clinical laboratories. Taking into account that there is so far no SARS case reported in Belgium  as well as in other countries in the world, and based on a scientific risk assessment related to the contained use of biological agents, the SARS-CoV was classified as a Risk Group 3 agent. In relation to the reported biosafety assessment, the SARS-CoV should be handled in appropriate biosafety containment levels in order to avoid laboratory acquired infections and spread of the disease in the human population and the environment. Therefore, diagnostic activities with inactivated clinical specimens associated with SARS cases and specimens originating from countries where SARS is documented but not associated with SARS cases, should be performed under Biosafety Level 2 (BSL-2) conditions. Diagnostic activities involving non-inactivated clinical specimens associated with SARS should be carried out under BSL-2 containment with BSL-3 safety equipment and work practices. Culture of SARS-CoV and all research activities involving SARS-CoV require a BSL-3 containment</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><custom1><style face="normal" font="default" size="100%">360</style></custom1><section><style face="normal" font="default" size="100%">128</style></section></record></records></xml>