<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Ron-Román</style></author><author><style face="normal" font="default" size="100%">Ron-Garrido, Lenin</style></author><author><style face="normal" font="default" size="100%">Abatih, Emmanuel</style></author><author><style face="normal" font="default" size="100%">Maritza Celi-Erazo</style></author><author><style face="normal" font="default" size="100%">Laura Vizcaíno-Ordóñez</style></author><author><style face="normal" font="default" size="100%">Jaime Calva-Pacheco</style></author><author><style face="normal" font="default" size="100%">Pablo González-Andrade</style></author><author><style face="normal" font="default" size="100%">Berkvens, Dirk</style></author><author><style face="normal" font="default" size="100%">Washington Benítez-Ortíz</style></author><author><style face="normal" font="default" size="100%">Jef Brandt</style></author><author><style face="normal" font="default" size="100%">David Fretin</style></author><author><style face="normal" font="default" size="100%">Saegerman, Claude</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bayesian Evaluation of Three Serological Tests for Detecting Antibodies against  spp. among Humans in the Northwestern Part of Ecuador.</style></title><secondary-title><style face="normal" font="default" size="100%">Am J Trop Med Hyg</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ADOLESCENT</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Agglutination Tests</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibodies, Bacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Bayes Theorem</style></keyword><keyword><style  face="normal" font="default" size="100%">Brucella abortus</style></keyword><keyword><style  face="normal" font="default" size="100%">Brucellosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Cattle</style></keyword><keyword><style  face="normal" font="default" size="100%">cross-sectional studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Ecuador</style></keyword><keyword><style  face="normal" font="default" size="100%">Edetic Acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Enzyme-Linked Immunosorbent Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Epidemiological Monitoring</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">middle aged</style></keyword><keyword><style  face="normal" font="default" size="100%">prevalence</style></keyword><keyword><style  face="normal" font="default" size="100%">Rose Bengal</style></keyword><keyword><style  face="normal" font="default" size="100%">Sensitivity and Specificity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2019 06</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">100</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Brucellosis is an important but neglected zoonosis that causes serious economic losses both in livestock and human populations. The aim of the present study was to estimate the true prevalence of brucellosis together with diagnostic sensitivity and specificity of three serological tests in humans of the northwestern part of Ecuador using a Bayesian approach adjusted for the dependencies among the multiple tests to avoid any misinterpretation. In addition, the causal agent responsible for human brucellosis was also identified. Using a total of 3,733 samples collected from humans in this area between 2006 and 2008, the prevalence of human brucellosis and the diagnostic test characteristics of the Rose Bengal fast agglutination test (RBT), Wright's slow agglutination test with ethylenediaminetetraacetic acid disodium salt dehydrate (EDTA) (SAT-EDTA), and indirect ELISA (iELISA) were estimated using a Bayesian approach. The estimated true prevalence of human brucellosis was 1% (credibility interval: 0.4-1.6). The sensitivities of iELISA and RBT were higher than and similar (95.1% and 95.0%, respectively) to those of SAT-EDTA (60.8%). Even though all tests indicated a high specificity (&amp;gt; 99.0%), the specificity of SAT-EDTA was highest (99.9%). The circulating strain in this study area was identified to be biotype 4 based on culture and microbiological characterization. The RBT and the iELISA are recommended for estimating the true prevalence of human brucellosis and/or for surveillance programs following their high sensitivities and specificities. The proposed strategy supports evidence-based medicine for clinicians and policy-makers to ensure appropriate preventive and control program of brucellosis worldwide.&lt;/p&gt;
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