<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kostoula Arvaniti</style></author><author><style face="normal" font="default" size="100%">George Dimopoulos</style></author><author><style face="normal" font="default" size="100%">Massimo Antonelli</style></author><author><style face="normal" font="default" size="100%">Koen Blot</style></author><author><style face="normal" font="default" size="100%">Ben Creagh-Brown</style></author><author><style face="normal" font="default" size="100%">Mieke Deschepper</style></author><author><style face="normal" font="default" size="100%">Dylan de Lange</style></author><author><style face="normal" font="default" size="100%">Jan De Waele</style></author><author><style face="normal" font="default" size="100%">Yalim Dikmen</style></author><author><style face="normal" font="default" size="100%">Christian Eckmann</style></author><author><style face="normal" font="default" size="100%">Sharon Einav</style></author><author><style face="normal" font="default" size="100%">Guy Francois</style></author><author><style face="normal" font="default" size="100%">Hans Fjeldsoee-Nielsen</style></author><author><style face="normal" font="default" size="100%">Massimo Girardis</style></author><author><style face="normal" font="default" size="100%">Bojan Jovanovic</style></author><author><style face="normal" font="default" size="100%">Matthias Lindner</style></author><author><style face="normal" font="default" size="100%">Despoina Koulenti</style></author><author><style face="normal" font="default" size="100%">Sonia Labeau</style></author><author><style face="normal" font="default" size="100%">Jeffrey Lipman</style></author><author><style face="normal" font="default" size="100%">Fernando Lipovestky</style></author><author><style face="normal" font="default" size="100%">Luis Daniel Umezawa Makikado</style></author><author><style face="normal" font="default" size="100%">Emilio Maseda</style></author><author><style face="normal" font="default" size="100%">Adam Mikstacki</style></author><author><style face="normal" font="default" size="100%">Philippe Montravers</style></author><author><style face="normal" font="default" size="100%">José Artur Paiva</style></author><author><style face="normal" font="default" size="100%">Cecilia Pereyra</style></author><author><style face="normal" font="default" size="100%">Jordi Rello</style></author><author><style face="normal" font="default" size="100%">Jean-Francois Timsit</style></author><author><style face="normal" font="default" size="100%">Dana Tomescu</style></author><author><style face="normal" font="default" size="100%">Vogelaers, Dirk</style></author><author><style face="normal" font="default" size="100%">Blot, Stijn</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">Abdominal Sepsis Study (AbSeS) Group on behalf of the Trials Group of the European Society of Intensive Care Medicine</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Epidemiology and age-related mortality in critically ill patients with intra-abdominal infection or sepsis: an international cohort study.</style></title><secondary-title><style face="normal" font="default" size="100%">Int J Antimicrob Agents</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Cohort Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Critical Illness</style></keyword><keyword><style  face="normal" font="default" size="100%">Cross Infection</style></keyword><keyword><style  face="normal" font="default" size="100%">Hospital Mortality</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">intensive care units</style></keyword><keyword><style  face="normal" font="default" size="100%">Intraabdominal Infections</style></keyword><keyword><style  face="normal" font="default" size="100%">middle aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Peritonitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Prospective Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Sepsis</style></keyword><keyword><style  face="normal" font="default" size="100%">Shock, Septic</style></keyword><keyword><style  face="normal" font="default" size="100%">Young adult</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2022 Jul</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">60</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;OBJECTIVE: &lt;/b&gt;To describe epidemiology and age-related mortality in critically ill older adults with intra-abdominal infection.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;METHODS: &lt;/b&gt;A secondary analysis was undertaken of a prospective, multi-national, observational study (Abdominal Sepsis Study, ClinicalTrials.gov #NCT03270345) including patients with intra-abdominal infection from 309 intensive care units (ICUs) in 42 countries between January and December 2016. Mortality was considered as ICU mortality, with a minimum of 28 days of observation when patients were discharged earlier. Relationships with mortality were assessed by logistic regression analysis.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;RESULTS: &lt;/b&gt;The cohort included 2337 patients. Four age groups were defined: middle-aged patients [reference category; 40-59 years; n=659 (28.2%)], young-old patients [60-69 years; n=622 (26.6%)], middle-old patients [70-79 years; n=667 (28.5%)] and very old patients [≥80 years; n=389 (16.6%)]. Secondary peritonitis was the predominant infection (68.7%) and was equally prevalent across age groups. Mortality increased with age: 20.9% in middle-aged patients, 30.5% in young-old patients, 31.2% in middle-old patients, and 44.7% in very old patients (P&amp;lt;0.001). Compared with middle-aged patients, young-old age [odds ratio (OR) 1.62, 95% confidence interval (CI) 1.21-2.17], middle-old age (OR 1.80, 95% CI 1.35-2.41) and very old age (OR 3.69, 95% CI 2.66-5.12) were independently associated with mortality. Other independent risk factors for mortality included late-onset hospital-acquired intra-abdominal infection, diffuse peritonitis, sepsis/septic shock, source control failure, liver disease, congestive heart failure, diabetes and malnutrition.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;CONCLUSIONS: &lt;/b&gt;For ICU patients with intra-abdominal infection, age &amp;gt;60 years was associated with mortality; patients aged ≥80 years had the worst prognosis. Comorbidities and overall disease severity further compromised survival. As all of these factors are non-modifiable, it remains unclear how to improve outcomes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue></record></records></xml>