<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Louiza S. Velentzis</style></author><author><style face="normal" font="default" size="100%">Megan A. Smith</style></author><author><style face="normal" font="default" size="100%">Kate T; Simms</style></author><author><style face="normal" font="default" size="100%">Jie-Bin Lew</style></author><author><style face="normal" font="default" size="100%">Michaela Hall</style></author><author><style face="normal" font="default" size="100%">Suzanne Hughes</style></author><author><style face="normal" font="default" size="100%">Susan Yuill</style></author><author><style face="normal" font="default" size="100%">James Killen</style></author><author><style face="normal" font="default" size="100%">Adam Keane</style></author><author><style face="normal" font="default" size="100%">Katherine Butler</style></author><author><style face="normal" font="default" size="100%">Jessica Darlington-Brown</style></author><author><style face="normal" font="default" size="100%">Harriet Hui</style></author><author><style face="normal" font="default" size="100%">Brotherton, Julia</style></author><author><style face="normal" font="default" size="100%">Rachel Skinner</style></author><author><style face="normal" font="default" size="100%">Brand, A</style></author><author><style face="normal" font="default" size="100%">Lara Roeske</style></author><author><style face="normal" font="default" size="100%">Stella Heley</style></author><author><style face="normal" font="default" size="100%">Jonathan Carter</style></author><author><style face="normal" font="default" size="100%">Deborah Bateson</style></author><author><style face="normal" font="default" size="100%">Ian Frazer</style></author><author><style face="normal" font="default" size="100%">Garland, Suzanne M</style></author><author><style face="normal" font="default" size="100%">Rebecca Guy</style></author><author><style face="normal" font="default" size="100%">Ian Hammond</style></author><author><style face="normal" font="default" size="100%">Paul Grogan</style></author><author><style face="normal" font="default" size="100%">M. Arbyn</style></author><author><style face="normal" font="default" size="100%">Castle, Philip E</style></author><author><style face="normal" font="default" size="100%">Marion Saville</style></author><author><style face="normal" font="default" size="100%">B. Armstrong</style></author><author><style face="normal" font="default" size="100%">Canfell, Karen</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pathways to a cancer-free future: A protocol for modelled evaluations to maximize the future impact of interventions on cervical cancer in Australia</style></title><secondary-title><style face="normal" font="default" size="100%">Gynecologic Oncology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">cervical cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cervical cancer prevention</style></keyword><keyword><style  face="normal" font="default" size="100%">EVALUATION</style></keyword><keyword><style  face="normal" font="default" size="100%">Health economics</style></keyword><keyword><style  face="normal" font="default" size="100%">Modelling</style></keyword><keyword><style  face="normal" font="default" size="100%">Simulation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan-03-2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">152</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;OBJECTIVE&lt;/strong&gt;&lt;br&gt;
Australia's HPV vaccination and HPV-based cervical screening programs are changing the landscape in cervical cancer prevention. We aim to identify areas which can make the biggest further impact on cervical cancer burden. This protocol describes the first stage of a program of work called Pathways-Cervix that aims to generate evidence from modelled evaluations of interventions across the cervical cancer spectrum.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;METHODS&lt;/strong&gt;&lt;br&gt;
Based on evidence from literature reviews and guidance from a multi-disciplinary Scientific Advisory Committee (SAC), the most relevant evaluations for prevention, diagnosis and treatment were identified.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;RESULTS&lt;/strong&gt;&lt;br&gt;
Priority evaluations agreed by the SAC included: increasing/decreasing and retaining vaccination uptake at the current level; vaccinating older women; increasing screening participation; methods for triaging HPV-positive women; improving the diagnosis of cervical intraepithelial neoplasia (CIN) and cancer; treating cervical abnormalities and cancer; and vaccinating women treated for CIN2/3 to prevent recurrence. Evaluations will be performed using a simulation model, Policy1-Cervix previously used to perform policy evaluations in Australia. Exploratory modelling of interventions using idealised scenarios will initially be conducted in single birth cohorts. If these have a significant impact on findings then evaluations with more realistic assumptions will be conducted. Promising strategies will be investigated further by multi-cohort simulations predicting health outcomes, resource use and cost outcomes.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;CONCLUSIONS&lt;/strong&gt;&lt;br&gt;
Pathways-Cervix will assess the relative benefits of strategies and treatment options in a systematic and health economic framework, producing a list of ‘best buys’ for future decision-making in cervical cancer control.&lt;/p&gt;
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