Imported malaria and artemisinin-based combination therapy failure in travellers returning to Belgium: A retrospective study.

Last updated on 31-1-2022 by Javiera Rebolledo Romero

Peer reviewed scientific article





BACKGROUND: Malaria (Plasmodium spp) remains a top cause of travel-associated morbidity among European residents. Here, we describe recent trends of imported malaria to Belgium and characterize the first cases of P.falciparum failure to artemisinin-based combination therapy (ACT). METHODS: National surveillance data and registers from national reference laboratory were used to investigate malaria cases and ACT failures in the past 20 years. Recurrent infections were confirmed by pfmsp genotyping and polymorphisms in drug resistance-associated genes pfk13, pfcrt, pfmdr1, pfpm2, pfap2mu an…

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