Minimal number of chromatographic test parameters for the characterisation of reversed-phase liquid chromatographic stationary phases

Last updated on 23-8-2019 by Anonymous (not verified)

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Peer reviewed scientific article

SCIENSANO

Abstract:

This paper focuses on the classification or differentiation of RP-HPLC columns based on measured chromatographic properties. A chemometric study has been conducted on a published data set consisting of 85 RP-HPLC columns and on a data set consisting of 47 self-tested columns. Principal component analysis enables determination of the number of parameters necessary for a rational differentiation. The results show that reducing the number of parameters for such differentiation still allows classification of the columns just as a higher number did. It is shown that three test parameters produce…

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