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Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat36548

Last updated on 23-8-2019 by Anonymous (not verified)

Public Access

Published

Peer reviewed scientific article

DOI : http://dx.doi.org/10.1016/j.tube.2011.05.003

Authors

Heng,Y.; Seah,P.G.; Siew,J.Y.; Tay,H.C.; Singhal,A.; Vanessa Mathys; Kiass,M.; Bifani,P.; Dartois,V.; Herve,M.

Keywords

  1. 0
  2. Activity
  3. Animals
  4. Anoxia
  5. article
  6. cause
  7. disease
  8. Disease Models,Animal
  9. Diseases
  10. DRUG
  11. Drug Resistance
  12. electronic
  13. Evaluating
  14. Female
  15. Granuloma
  16. im
  17. immunohistochemistry
  18. in vivo
  19. INFECTION
  20. Institute
  21. IS
  22. journal
  23. Lung
  24. microbiology
  25. MODEL
  26. Mycobacterium
  27. Mycobacterium tuberculosis
  28. Nitroimidazoles
  29. Oxygen
  30. pathogenicity
  31. pathology
  32. pharmacology
  33. rats
  34. region
  35. Research
  36. Research Support
  37. resistance
  38. result
  39. results
  40. SB - IM
  41. State
  42. Tension
  43. Tuberculosis
  44. Tuberculosis,Pulmonary
  45. use

Abstract:

Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for evaluating anaerobic drug activity in vivo
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