N-acetyl-(1-amino-2-naphthol-6-sulphonic acid), a common metabolite of sunset yellow FCF, orange GGN and 1-amino-2-naphthol-6-sulphonic acid in rat urine

Last updated on 23-8-2019 by Anonymous (not verified)

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Sunset Yellow FCF, Orange GGN and 1-amino-2-naphthol-6-sulphonic acid (ANSA) were administered to male Wistar rats by stomach intubation. Aromatic sulphonic acids excreted in 24-h urines after enzymatic cleavage of the azo link in the dyes were isolated using a thoroughly elaborated ion-pair extraction method and further separated by means of a reversed-phase ion-pair liquid chromatographic system. Blank 24-h rat urines were extracted and run at the same time under identical analytical circumstances. In addition to the peaks corresponding to sulphanilic and metanilic acid and their N-acetyl…

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