Optimisation of a liquid chromatography-tandem mass spectrometric method for the determination of acrylamide in foods

Last updated on 11-6-2020 by Jill Alexandre

Public Access


Peer reviewed scientific article



A robust and fitted routine method resulting from an analytical optimisation has been applied for the determination of acrylamide in several foods including mainly potato and cereal products. For the sample treatment, different materials were evaluated for filtration and purification of the extract. To increase the performances in terms of sensitivity, a preconcentration to small volume was introduced before liquid chromatography coupled to tandem mass spectrometry analysis on a µBondapak C18 column using d3-acrylamide as internal standard. For identification, relative retention time and tw…

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