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Positive interference of merthiolate in the TDx digoxin assay in control samples used in the Belgian External Quality Assessment (EQA) Scheme138

Last updated on 23-8-2019 by Anonymous (not verified)

Public Access

Published

Peer reviewed scientific article

SCIENSANO

Authors

Devleeschouwer,N.; Libeer,J.C.; Schiettecatte,J.; Virginie Maes; Demolder,J.; Debusschere,P.M.; F. Gorus

Keywords

  1. 0
  2. a
  3. article
  4. AS
  5. assessment
  6. Belgian
  7. Belgium
  8. Biology
  9. blood
  10. Brussels
  11. Clinical
  12. Comparative Study
  13. Control
  14. Digoxin
  15. effect
  16. epidemiology
  17. EQA
  18. external
  19. External quality assessment
  20. External quality assessment scheme
  21. False Positive Reactions
  22. Fluorescence Polarization Immunoassay
  23. Humans
  24. Hydrocortisone
  25. Hygiene
  26. im
  27. Immunoassay
  28. Interference
  29. IS
  30. IT
  31. journal
  32. matrix
  33. observed
  34. ORIGIN
  35. present
  36. Print
  37. Progesterone
  38. Quality
  39. Quality Control
  40. Radioimmunoassay
  41. Reagent Kits,Diagnostic
  42. result
  43. results
  44. Sample
  45. Samples
  46. SB - IM
  47. stress
  48. study
  49. Thimerosal
  50. use
  51. work

Abstract:

We investigated the possible origin of the spuriously high results observed with the Abbott TDx Immunoassay in the 1991 Belgian external quality assessment scheme for digoxin. The present work ascribes this discrepancy to a matrix effect induced by the addition of merthiolate as preservative to the control samples. It consequently stresses the importance of avoiding the use of this compound for preparing such samples
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