Pyrogen testing of phage therapeutic products

Last updated on 26-9-2023 by Marie Willocx

Scientific poster, presentation or proceeding




The use of phage therapeutic products has gained popularity in Belgium these last years, with treatments provided to more than 100 patients, against more than 10 different bacterial species. Therapeutic phage products are produced  in a bacterial host strain, hence pyrogen contamination (e.g. cell wall debris) is a major safety concern as these pro-inflammatory agents can cause unwanted clinical reactions with potential detrimental outcome. The most common and potent pyrogens are endotoxins, components of the cell wall of gram-negative bacteria which are released upon bacterial lysis. …

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