Urease activity represents an alternative pathway for Mycobacterium tuberculosis nitrogen metabolism31064

Last updated on 23-8-2019 by Anonymous (not verified)

Public Access


Peer reviewed scientific article


Urease represents a critical virulence factor for some bacteria species through its alkalizing effect that helps neutralize the acidic microenvironment of the pathogen. In addition, urease serves as a nitrogen source provider for bacterial growth. Pathogenic mycobacteria express a functional urease but its role during infection has yet to be characterized. Here, we constructed a urease-deficient M. tuberculosis (Mtb) strain and confirmed the alkalizing effect of the urease activity within the mycobacteria-containing vacuole in resting macrophages but not in the more acidic phagolysosomal co…

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