Which high-risk HPV assays fulfil criteria for use in primary cervical cancer screening?

Last updated on 15-6-2023 by Marie Malingreau

Public Access


Peer reviewed scientific article




Several countries are in the process of switching to high-risk human papillomavirus (hrHPV) testing for cervical cancer screening. Given the multitude of available tests, validated assays which assure high-quality screening need to be identified. A systematic review was conducted to answer the question which hrHPV tests fulfil the criteria defined by an international expert team in 2009, based on reproducibility and relative sensitivity and specificity compared to Hybrid Capture-2 or GP5+/6+ PCR–enzyme immunoassay. These latter two hrHPV DNA assays were validated in large randomized trials…

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