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In-vivo expressed Mycobacterium tuberculosis antigens recognised in three mouse strains after infection and BCG vaccination.

Ottenhoff, Tom H M Source: NPJ Vaccines, Volume 6, Issue 1 (2021) Abstract: Novel tuberculosis (TB)-vaccines preferably should (i) boost host immune responses induced by previous BCG vaccination and (ii) be ...

Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation.

hypoxia and starvation. This suggests that the target inhibition may not fully explain the bactericidal activity of the drug. Here, we report that INH rapidly increased BCG cellular ATP levels and enhanced ...

Innate signaling by mycolate esters of the cell wall of Mycobacterium tuberculosis and relevance for development of adjuvants for subunit vaccines

Bacille of Calmette and Guérin (BCG). However, its efficacy is extremely variable against the contagious form of TB  — pulmonary TB  — in adults and adolescents (ranging from 0 to 80%). Therefore, to ...

Increased vancomycin susceptibility in mycobacteria: a new approach to identify synergistic activity against multi-drug resistant mycobacteria36969

Source: Antimicrob.Agents Chemother., Volume 59, Number 5060, p.5057- 5060 (2015) Keywords: a Activity Agent Agents Antibiotic antibiotics approach approaches article BCG Belgium Biology Brussels Bruxelles ...

Increased B and T Cell Responses in M. bovis Bacille Calmette-Guerin Vaccinated Pigs Co-Immunized with Plasmid DNA Encoding a Prototype Tuberculosis Antigen

Issue 7, p.e0132288 (2015) Keywords: a ALL alternative an Animal Animals antibodies Antibody article AS BCG Belgium Biology Brussels Cell cells Combination concept Control de delivery denmark Dna DNA ...

Evaluation of the Speed-Oligo Mycobacteria assay for the identification of nontuberculous mycobacteria.

isolates) belonging to 13 different species (Mycobacterium intracellulare, M. fortuitum, M. gordonae, M. kansasii, M. marinum, M. peregrinum, M. scrofulaceum, M. abscessus, M. bovis BCG, M. chelonae, M. ...

DNA vaccines against tuberculosis.

Antigens, Bacterial BCG Vaccine Humans Immunization, Secondary Mycobacterium tuberculosis T-Lymphocytes, Cytotoxic Tuberculosis, Pulmonary Vaccination Vaccines, DNA Abstract: INTRODUCTION: Tuberculosis (TB) ...

The immunodominant T-cell epitopes of the mycolyl-transferases of the Antigen 85 complex of M. tuberculosis34076

candidate antigens. Ag85A and Ag85B, initially purified from Mycobacterium bovis bacillus Calmette-Guerin (BCG)/Mycobacterium tuberculosis culture filtrate respectively, induce strong T-cell proliferation and ...

Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice.

induced by M. bovis BCG. The mycolactone toxin is an obvious candidate for a vaccine, but by virtue of its chemical structure, this toxin is not immunogenic in itself. However, antibodies against some of ...

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