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The 2021 WHO catalogue of complex mutations associated with drug resistance: A genotypic analysis.
for all drugs except ethionamide (91·4%), moxifloxacin (91·6%) and ethambutol (93·3%). Only two resistance mutations were classified for bedaquiline, delamanid, clofazimine, and linezolid as prevalence ...
Deep amplicon sequencing for culture-free prediction of susceptibility or resistance to 13 anti-tuberculous drugs.
involved pyrazinamide, ethambutol, and ethionamide, and low-level rifampicin- or isoniazid-resistance mutations, all notoriously prone to phenotypic testing variability. Only 2 of 91 (2.2%) resistance ...
Amélioration de l'activité thérapeutique de l'ethionamide.
Publication Type: Scientific poster, presentation or proceeding Authors: Vanessa Mathys; FARES-VRGT Source: FARES annual meeting, Issue FARES (2015) Keywords: de Service: Bacterial diseases Maladies bactériennes Bacteriële ziekten Category: C31 ...
Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study9
assessment at Belgium Biology Brussels care Cell Clinical Concordance de detection disease Diseases DRUG drug effects Drug Resistance drugs e electronic environment Establish estimation ET Ethionamide Europe ...
False-positive rifampicin resistance on Xpert® MTB/RIF caused by a silent mutation in the rpoB gene.
Aged Amikacin Amino Acid Sequence Antibiotics, Antitubercular Bacterial Proteins DNA-Directed RNA Polymerases Drug Resistance, Multiple, Bacterial Ethambutol Ethionamide Fluoroquinolones Genotype Humans ...
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors31058
Design DRUG Drug Design drug effects Drug Synergism electronic Ethionamide EVALUATION exposure expression France Human im IS journal Macrophages metabolism mice microbiology Microsomes,Liver ...
Synthetic EthR inhibitors boost antituberculous activity of ethionamide36849
electronic ET Ethionamide France Hydrogen Bonding identify im improve index interaction IS journal Ligands metabolism mice Models,Molecular Mycobacterium Mycobacterium tuberculosis national Oxadiazoles ...
Molecular characterization of genes associated with ethionamide resistance in Mycobacterium tuberculosis clinical isolates and spontaneous mutants
American Society for Microbiology (ASM), NA (2006) Keywords: Clinical Ethionamide gene general Genes meeting Molecular Mycobacterium Mycobacterium tuberculosis resistance Tuberculosis Health Topics: Health ...
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.
a cryptic alternative bioactivation pathway of ethionamide in M. tuberculosis, circumventing the classic activation pathway in which resistance mutations have now been observed. The first-of-its-kind ...
The small-molecule SMARt751 reverses resistance to ethionamide in acute and chronic mouse models of tuberculosis.
Transl Med, Volume 14, Issue 643 (2022) Keywords: Animals Antitubercular Agents Ethionamide mice Mycobacterium tuberculosis Prodrugs Tuberculosis Abstract: The sensitivity of, the pathogen that causes ...