Search results - 15 results
Retrospective evaluation of routine whole genome sequencing of Mycobacterium tuberculosis at the Belgian National Reference Center, 2019.
100% (pyrazinamide, PZA). The negative predictive value was above 95% for these four first-line drugs. A positive predictive value of 100% was calculated for INH and PZA, 80% for RIF and 45% for EMB. ...
Deep amplicon sequencing for culture-free prediction of susceptibility or resistance to 13 anti-tuberculous drugs.
involved pyrazinamide, ethambutol, and ethionamide, and low-level rifampicin- or isoniazid-resistance mutations, all notoriously prone to phenotypic testing variability. Only 2 of 91 (2.2%) resistance ...
Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe.
a new software implementation. Improvements include i) an updated mutation catalogue giving greater sensitivity to detect pyrazinamide resistance, ii) support for user-defined resistance catalogues, iii) ...
RNA-based drug susceptibility testing of Mycobacterium tuberculosis
v and clinical Mtb strains on ten anti- TB drugs including Bedaquiline, Pyrazinamide and Delamanid was determined, to identify RNA Biomarkers. In a next phase, the RNA-based DST was developed in 96 well ...
Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing
drugs isoniazid, rifampin, ethambutol, and pyrazinamide for isolates from 16 countries across six continents. For each isolate, mutations associated with drug resistance and drug susceptibility were ...
A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study.
profiles; phenotypic resistance to isoniazid, rifampicin, ethambutol, pyrazinamide, and capreomycin; and corresponding drug resistance mutations. We whole-genome sequenced all Mycobacterium tuberculosis ...
External quality assessment for tuberculosis diagnosis and drug resistance in the European Union: A five year multicentre implementation study
performance prevention problems Pyrazinamide Quality QUALITY ASSURANCE resistance result results SB- IM specific State States study Sweden System Systems Test TESTING training Tuberculosis United Kingdom ...
Evaluation externe de qualité 2015 en microbiologie. Identification de mycobactéries et test de sensibilité de Mycobacterium tuberculosis à l'isoniazide (INH), la rifampicine (RMP), l'éthambutol (EMB) et facultatif la pyrazinamide (PZA)
Publication Type: Sci. report, recommendat°, guidance doc., directive, monograph Authors: Kris Vernelen Source: WIV-ISP, Bruxelles, p.11 (2016) Service: Quality of laboratories Kwaliteit van laboratoria Qualité des laboratoires ...
Externe kwaliteitsevaluatie in microbiologie 2015 Identificatie van mycobacteriën gevoeligheidsbepaling vanMycobacterium tuberculosis complex isoniazide (INH), rifampicine (RMP), ethambutol (EMB) en facultatief pyrazinamide (PZA)
Publication Type: Sci. report, recommendat°, guidance doc., directive, monograph Authors: Kris Vernelen Source: WIV-ISP, Brussel, p.11 (2016) Service: Quality of laboratories Kwaliteit van laboratoria Qualité des laboratoires ...
Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study9
outcome paris pathogen Patient Patient Care patients pharmacology portugal proportion protocol public public health Public-health Pulmonary Pyrazinamide region resistance result results SB- IM SCREENING ...