Search results - 11 results
Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation.
inhibition. The activity of isoniazid (INH), a key first-line bactericidal antituberculosis drug currently known to inhibit mycolic acid synthesis, becomes extremely poor under stress conditions, such as ...
Falsification of biotechnology drugs: current dangers and/or future disasters?
antibodies), complexity (e.g., isoforms, glycosylations) and different synthesis techniques (chemical synthesis, recombinant expression, native protein isolation) result in a wide range of putative health risks. ...
Impurity profiling of the most frequently encountered falsified polypeptide drugs on the Belgian market
Volume 188, Number 807 (2018) Abstract: Advances in biotechnology and the chemical synthesis of peptides have made biopharmaceuticals and synthetic peptide drugs viable pharmaceutical compounds today and ...
Synthesis and in vitro investigation of halogenated 1,3-bis(4-nitrophenyl)triazenide salts as antitubercular compounds
Caljon; Louis Maes; Peter Delputte; Paul Cos; Janez šmrlj; Cappoen, Davie Source: Chemical Biology & Drug Design, Volume 91, Issue 2, Number 640 (2018) Service: Évaluation des risques et de ...
Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice.
induced by M. bovis BCG. The mycolactone toxin is an obvious candidate for a vaccine, but by virtue of its chemical structure, this toxin is not immunogenic in itself. However, antibodies against some of ...
Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase.
effect, viral RNA synthesis and the production of infectious virus were 0.3±0.1μM, 0.05±0.01μM and 0.3±0.04μM, respectively. Furthermore, BBP / CSFA-0 inhibits the in vitro replication of the classical ...
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors31058
Keywords: 0 a Administration,Oral Agent Agents Animals antagonists & inhibitors Antibiotic Antitubercular Agents article Cell Line chemical synthesis chemistry Combination Control Crystallography,X-Ray de ...
Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure4392
Bioorg.Med.Chem.Lett., Volume 18, Issue 4, Number 1353, p.1350- 1353 (2008) Keywords: 0 a Activity Aequorin agonists an Analgesics Analgesics,Opioid Animals antagonists & inhibitors article AS Calcium chemical ...
Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2)4395
Volume 50, Issue 3, Number 520, p.512- 520 (2007) Keywords: 0 a Aequorin Agent Agents agonists Analgesics Animals antagonists & inhibitors article AS Binding Sites brain Calcium chemical synthesis ...
Insect neuropeptide and peptide hormone receptors: current knowledge and future directions4400
Factor beta Research Research Support result REVIEW SB- IM specific Abstract: Peptides form a very versatile class of extracellular messenger molecules that function as chemical communication signals ...