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Development and validation of a targeted LC-MS/MS quantitation method to monitor cell culture expression of tetanus neurotoxin during vaccine production

Publication Type: Peer reviewed scientific article Authors: Antoine Francotte; Raphael Esson; Eric Abachin; Melissa Vanhamme; Alexandre Dobly; Bruce Carpick; Sylvie Uhlrich; Jean-François Dierick; Celine Vanhee Source: Talanta, Volume 236 (2022) Health To ...

Regulation of Clostridium tetani Neurotoxin Expression by Culture Conditions

Publication Type: Peer reviewed scientific article Authors: Jeroen L A Pennings; Eric Abachin; Raphael Esson; Hennie Hodemaekers; Antoine Francotte; Jean-Baptiste Claude; Celine Vanhee; Sylvie Uhlrich; Rob J. Vandebriel Source: Toxins, Volume 14, Issue 1 ...

Characterization and risk identification of falsified medicines and adulterated dietary supplements

galenic and microbial quality, showing failures for impurity content, dissolution and microbial purity (presence of neurotoxin producing fungi). This project showed clearly that chemical quality of illegal ...

Verification of a non-validated reference method according to ISO 16140-3: an example: Detection of botulinum neurotoxin producing Clostridia following ISO/TS 17919

Publication Type: Scientific poster, presentation or proceeding Authors: Tom Van Nieuwenhuysen Source: BSFM 25th conference on Food Microbiology (2021) Keywords: C. botulinum ISO 16140 Verification Health Topics:  Botulisme Botulism Botulisme Service:  Pa ...

Influence of reduced levels or suppression of sodium nitrite on the outgrowth and toxinogenesis of psychrotrophic Clostridium botulinum Group II type B in cooked ham.

encountered along the supply chain. Enumeration of C. botulinum and detection of the botulinum neurotoxin type B (BoNT/B) were performed in triplicate at different storage times. Under these experimental ...

Detection of toxins involved in foodborne diseases caused by Gram‐positive bacteria

neurotoxins of Clostridium botulinum, enterotoxin of Clostridium perfringens, and a family of enterotoxins produced by Staphylococcus aureus and some other staphylococci. These toxins are the most important ...

Quantification of Tetanus neurotoxin producted by Clostridium tetani strains

Publication Type: Scientific poster, presentation or proceeding Authors: Antoine Francotte; Celine Vanhee Source: VAC2VAC anual meeting (2019) Health Topics:  Effectiveness and safety of vaccines, medicines and health products- Quality of medical laborato ...

Very Long Persistence of Botulinum Toxin B in a Patient’s Serum

Diseases Journal, Volume 10, Issue 1, Number 191 (2018) Keywords: Bioassay BoNT Botulinum neurotoxins Botulism Clostridium botulinum Immunocompromised Abstract: Background: Botulinum toxins (BoNT) type A, B, ...

Construction of Nontoxigenic Mutants of Nonproteolytic Clostridium botulinum NCTC 11219 by Insertional Mutagenesis and Gene Replacement.

can grow and produce botulinum neurotoxin during refrigerated storage. The principles of control of gIICb by conventional food processing and preservation methods have been well investigated and ...

Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test.

Andreas Source: Toxins (Basel), Volume 7, Issue 12, p.5035-54 (2015) Keywords: Animals Botulinum Toxins Female Laboratory Proficiency Testing Lethal Dose 50 mice Neurotoxins Phrenic Nerve Recombinant ...

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