Search results - 328 results

Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health.

quinones altertoxin I (ATX-I), ATX- II, ATX- III, alterperylenol (ALP), and stemphyltoxin III (STTX- III) showed in vitro genotoxic and mutagenic properties. Of all identified Alternaria toxins, the ...

Pyrogen testing of phage therapeutic products

is pivotal to limit the risk of non-endotoxin contamination. These pyrogens can be detected by the monocyte activation test (MAT), which employs human blood cells to quantify pyrogenicity in vitro. In ...

A roadmap for regulatory implementation of in vitro models for evaluation of vaccine efficacy

Publication Type: Scientific poster, presentation or proceeding Authors: R. J. Vandebriel; L. Tesolin; K. Veenstra; K. Huber Source: EVI, Niagara falls, Canada (2023) Keywords: in vitro model ...

Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.

towards a more human-relevant in vitro genotoxicity testing strategy without the use of experimental animals. Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  ...

Rational arguments for regulatory acceptance of consistency testing: benefits of non-animal testing over release testing of vaccines.

techniques to measure critical quality attributes. However, introduction of in vitro alternatives to replace in vivo release assays of authorized vaccines is challenging. AREAS COVERED: This report describes ...

Development of a Droplet Digital PCR to Monitor SARS-CoV-2 Omicron Variant BA.2 in Wastewater Samples

used as a complementary method to other SARS-CoV-2 surveillance systems. It allows the emergence and spread of infections and SARS-CoV-2 variants to be monitored in time and place. This study presents an ...

P20-10: Microcystin-LR and aflatoxin M1 contamination in dairy milk samples and their combined in vitro hepatotoxicity

Publication Type: Peer reviewed scientific article Authors: Mohamed F. Abdallah; Van Camp, C.; Recote, J. May; Wannes Van Hassel *; Julien Masquelier *; A. Rajkovic Source: Toxicology Letters, Volume 384 (2023) Health Topics:  Food consumption and food sa ...

The consistency approach for the substitution of in vivo testing for the quality control of established vaccines: practical considerations and progressive vision

Publication Type: Peer reviewed scientific article Authors: L. Tesolin; J.-F. Dierick; Wim Van Molle Source: Open Research Europe (2022) Keywords: human vaccines in vitro testing in vivo testing ...

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