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Comparative Profiling of Ubiquitin Proteasome System Interplay with Influenza A Virus PB2 Polymerase Protein Recapitulating Virus Evolution in Humans

Louis Jones; Sandie Munier; Nadia Naffakh; Sylvie van der Werf; Yves Jacob; Murielle Masson; Caroline Demeret; Martin Schwemmle Source: mSphere, Volume 2, Issue 6 (2017) Keywords: INFLUENZA interactomic ...

Systematic identification of hypothetical bacteriophage proteins targeting key protein complexes of pseudomonas aeruginosa

assays, we further mapped the inhibitory interaction of gp12 of phage 14-1 to the alpha subunit of the RNA polymerase. Together, our data demonstrate the powerful use of interactomics to unravel the ...

Attributes of short linear motifs.

mediated by large, structured domains. However, it has become clear that the interactome comprises a wide range of binding interfaces with varying degrees of flexibility, ranging from rigid globular domains ...

Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription.

that are responsible for seasonal epidemics, but the interplay between viral proteins and cellular exonucleases has never been specifically studied. Here, using a stringent interactomics screening ...

Viral interference of the bacterial RNA metabolism machinery.

a unique interaction between a protein encoded by the giant myovirus phiKZ and the Pseudomonas aeruginosa RNA degradosome. Crystallography, site-directed mutagenesis and interactomics approaches revealed ...

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