Search results - 19 results

The GENOMARK transcriptomic biomarker: a new approach methodology for genotoxicity (Qualitative and quantitative aspects)

Source: Joint 3R Symposium 2023 (2023) Keywords: genotoxicity NAMs transcriptomic biomarker Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des ...

An AOP-based IATA to pave the way toward animal-free genotoxicity testing

Publication Type: Scientific poster, presentation or proceeding Authors: Birgit Mertens Source: Joint 3R Symposium 2023, Brussels, Belgium (2023) Keywords: adverse outcome pathways genotoxicity ...

Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity- A roadmap for regulatory uptake

Birgit Mertens Source: Joint 3R Symposium, Brussels, Belgium (2023) Keywords: adverse outcome pathways Cardiotoxicity Integrated approaches to testing and assessment (IATA) pollutants Health Topics:  ...

Mixtures of genotoxicants: does the principle of additivity apply?

Publication Type: Scientific poster, presentation or proceeding Authors: Julie Sanders; Roel Anthonissen; George Johnson; Tamara Vanhaecke; Birgit Mertens Source: Joint 3R Symposium 2023, Brussels, ...

Laboratory Animal Science

Keywords: 3R Principe 3Rs animal testing ethics legislation Service:  Évaluation des risques et de l'impact sur la santé Risico- en gezondheidsimpactevaluatie Risk and health impact assessment Risques ...

Validation of an animal-free analytical method for the detection of bacterial endotoxins in human vaccines

3R (2023) Keywords: Endotoxin " vaccine " quality control " recombinant factor c " LAL Abstract: Sciensano, as official medicines control laboratory (OMCL) following ...

Replacement of Diphtheria and Tetanus potency challenge method by serology in mice

Publication Type: Scientific poster, presentation or proceeding Authors: J. Auquier Source: Annual OMCL Meeting 2023, EDQM, Madrid (2023) Keywords: 3R Diphtheria serology Tetanus vaccine Health ...

How to increase the visibility of expertise on New Approach Methodologies in Belgium

BSTE, Issue BSTE, Antwerp (2022) Keywords: 3R animal testing Knowledge sharing NAMs new approach methodologies open access database RE-Place replacement Service:  Évaluation des risques et de ...

Proposal for 3R reporting for Official Control Authority Batch Release

Publication Type: Scientific poster, presentation or proceeding Authors: Source: OMLC Annual meeting 2021- Common OCABR session, EDQM (extranet), Strasbourg, France (2021) Keywords: 3Rs EU reporting Vaccine quality control Health Topics:  Effectiveness an ...

Development of a multiplex immunoassay for simultaneous detection of antigens in DTaP vaccines

Virtual (2021) Keywords: 3R Vaccine Potency Abstract: Routine batch quality testing before vaccine release, notably for potency evaluation, still relies on animal use for several animal and human vaccines. ...

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