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Correlation of tacrolimus levels in peripheral blood mononuclear cells with histological staging of rejection after liver transplantation: preliminary results of a prospective study.

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Published

Peer reviewed scientific article

English

DOI : https://doi.org/10.1111/j.1432-2277.2011.01365.x [2]

Authors

Arnaud Capron [3]; Jan Lerut [4]; Dominique Latinne [5]; Rahier, Jacques [6]; Haufroid, Vincent [7]; Wallemacq, Pierre [8]

Keywords

  1. Adult [9]
  2. Aged [10]
  3. Cohort Studies [11]
  4. Drug Monitoring [12]
  5. Female [13]
  6. Graft Rejection [14]
  7. Humans [15]
  8. Immunosuppressive Agents [16]
  9. Leukocytes, Mononuclear [17]
  10. Liver [18]
  11. Liver Transplantation [19]
  12. Male [20]
  13. middle aged [21]
  14. Prospective Studies [22]
  15. Tacrolimus [23]
  16. Treatment Outcome [24]

Abstract:

Therapeutic drug monitoring of tacrolimus (TAC) is characterized by a complex relationship between trough blood TAC concentrations and therapeutic efficacy. This prospective study evaluates the predictive value of intrahepatic, peripheral blood mononuclear cells (PBMCs) and blood TAC concentrations during the early postliver transplantation (LT) period. In a cohort of 90 adult liver recipients under TAC-based monotherapy, liver biopsies were performed at day 7 post-LT, and PBMCs TAC concentrations were measured at day 1, 3, 5, and 7 post-LT. Both intrahepatic and PBMCs TAC concentrations we…
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Source URL:https://www.sciensano.be/en/biblio/correlation-tacrolimus-levels-peripheral-blood-mononuclear-cells-histological-staging-rejection

Links
[1] https://www.sciensano.be/sites/default/files/transplant_international_-_2011_-_capron_-_correlation_of_tacrolimus_levels_in_peripheral_blood_mononuclear_cells_with.pdf [2] https://doi.org/10.1111/j.1432-2277.2011.01365.x [3] https://www.sciensano.be/en/people/arnaud-capron/biblio [4] https://www.sciensano.be/en/biblio?f%5Bauthor%5D=179486&f%5Bsearch%5D=Jan%20Lerut [5] https://www.sciensano.be/en/biblio?f%5Bauthor%5D=179600&f%5Bsearch%5D=Dominique%20Latinne [6] https://www.sciensano.be/en/biblio?f%5Bauthor%5D=41736&f%5Bsearch%5D=Rahier%2C%20Jacques [7] https://www.sciensano.be/en/biblio?f%5Bauthor%5D=37023&f%5Bsearch%5D=Haufroid%2C%20Vincent [8] https://www.sciensano.be/en/biblio?f%5Bauthor%5D=48654&f%5Bsearch%5D=Wallemacq%2C%20Pierre [9] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=2724&f%5Bsearch%5D=Adult [10] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=2658&f%5Bsearch%5D=Aged [11] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=5628&f%5Bsearch%5D=Cohort%20Studies [12] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=19671&f%5Bsearch%5D=Drug%20Monitoring [13] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=2685&f%5Bsearch%5D=Female [14] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=37182&f%5Bsearch%5D=Graft%20Rejection [15] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=648&f%5Bsearch%5D=Humans [16] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=17544&f%5Bsearch%5D=Immunosuppressive%20Agents [17] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=30078&f%5Bsearch%5D=Leukocytes%2C%20Mononuclear [18] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=17622&f%5Bsearch%5D=Liver [19] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=37183&f%5Bsearch%5D=Liver%20Transplantation [20] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=2757&f%5Bsearch%5D=Male [21] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=2760&f%5Bsearch%5D=middle%20aged [22] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=19263&f%5Bsearch%5D=Prospective%20Studies [23] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=22887&f%5Bsearch%5D=Tacrolimus [24] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=17574&f%5Bsearch%5D=Treatment%20Outcome