HPV and head and neck cancers: Towards early diagnosis and prevention.
Peer reviewed scientific article
English
SCIENSANO
Authors
Luisa Galati [1]; Chiocca, Susanna [2]; Daria Duca [3]; Marta Tagliabue [4]; Cindy Simoens [5]; Gheit, Tarik [6]; M. Arbyn [7]; Tommasino, Massimo [8]Keywords
Abstract:
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with an increasing trend of its incidence. Alcohol consumption, smoking, and viral infections, such as the mucosal high-risk (HR) human papillomaviruses (HPVs) are major risk factors for HNSCC development. In particular, HR HPVs are mainly associated with a subset of oropharyngeal squamous cell carcinoma (OPSCC), while other head and neck sites are marginally affected by HPV infection. HPV16 is the most frequently HR HPV type associated with HNSCC. In contrast to the cervix, no screening programs or iden…