Immunogenicity and one-year boostability of a 3-dose intramuscular rabies pre-exposure prophylaxis schedule in adults receiving immunosuppressive monotherapy: a prospective single-Centre clinical trial.
Health and disease monitoring
Peer reviewed scientific article
English
SCIENSANO
Authors
Hannah M Garcia Garrido [1]; Bridget van Put [2]; Cornelis A de Pijper [3]; Cornelis Stijnis [4]; Martin P Grobusch [5]; Abraham Goorhuis [6]Keywords
Abstract:
BACKGROUND: For immunocompromised patients (ICPs), administration of rabies immunoglobulins (RIG) after exposure is still recommended regardless of prior vaccination, due to a lack of data. We aimed to assess the one-year boostability of a 3-dose rabies pre-exposure prophylaxis (PrEP) schedule in individuals using immunosuppressive monotherapy.
METHODS: In this prospective study, individuals on immunosuppressive monotherapy with a conventional immunomodulator (cIM) or a TNF-alpha inhibitor (TNFi) for a chronic inflammatory disease received a 3-dose intramuscular PrEP schedule (days 0,7,2…