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Isotypic neutralizing antibodies against mouse GCP-2/CXCL6 inhibit melanoma growth and metastasis

Public Access

Published

Peer reviewed scientific article

English

DOI : http://dx.doi.org/10.1016/j.canlet.2010.12.013 [1]

Authors

H. Verbeke [2]; Struyf,S. [3]; Berghmans,N. [4]; E. Van Coillie [5]; Opdenakker,G. [6]; Uyttenhove,C. [7]; J. Van Snick [8]; J. Van Damme [9]

Keywords

  1. )Melanoma [10]
  2. chemokine [11]
  3. Granulocyte chemotactic protein-2 (GCP-2 [12]

Abstract:

The chemokine granulocyte chemotactic protein (GCP)-2/CXCL6 promotes tumor growth as angiogenesis inducer and neutrophil chemoattractant. The neutralizing capacity and specificity of monoclonal mouse anti-murine (mu)GCP-2/CXCL6 antibodies were evidenced by granulocyte chemotaxis and signaling assays. The half-life of the non-antigenic antibody in the blood circulation was approximately 15 days. The titers remained constant upon weekly injection. Tumor growth and lymphogenic metastases of human melanoma over-expressing muGCP-2 were reduced in mice treated with anti-muGCP-2. Moreover, the dro…
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Source URL:https://www.sciensano.be/en/biblio/isotypic-neutralizing-antibodies-against-mouse-gcp-2-cxcl6-inhibit-melanoma-growth-and-metastasis

Links
[1] http://dx.doi.org/10.1016/j.canlet.2010.12.013 [2] https://www.sciensano.be/en/people/hannelien-verbeke/biblio [3] https://www.sciensano.be/en/biblio?f%5Bauthor%5D=1077&f%5Bsearch%5D=Struyf%2CS. [4] https://www.sciensano.be/en/biblio?f%5Bauthor%5D=29373&f%5Bsearch%5D=Berghmans%2CN. [5] https://www.sciensano.be/en/biblio?f%5Bauthor%5D=1491&f%5Bsearch%5D=E.%20Van%20Coillie [6] https://www.sciensano.be/en/biblio?f%5Bauthor%5D=23583&f%5Bsearch%5D=Opdenakker%2CG. [7] https://www.sciensano.be/en/biblio?f%5Bauthor%5D=23268&f%5Bsearch%5D=Uyttenhove%2CC. [8] https://www.sciensano.be/en/biblio?f%5Bauthor%5D=23265&f%5Bsearch%5D=J.%20Van%20Snick [9] https://www.sciensano.be/en/biblio?f%5Bauthor%5D=1083&f%5Bsearch%5D=J.%20Van%20Damme [10] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=35838&f%5Bsearch%5D=%29Melanoma [11] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=35824&f%5Bsearch%5D=chemokine [12] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=35837&f%5Bsearch%5D=Granulocyte%20chemotactic%20protein-2%20%28GCP-2