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PRECISION: the Belgian molecular profiling program of metastatic cancer for clinical decision and treatment assignment

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Peer reviewed scientific article

English

SCIENSANO

Authors

J. Thouvenin1,2 [2]; C. Van Marcke3 [3]; L. Decoster4 [4]; Gordana Raicevic [5]; K. Punie [6]; M. Vandenbulcke5 [7]; R. Salgado [8]; Els Van Valckenborgh [9]; B. Maes [10]; S. Joris [11]; D. Vander Steichel [12]; K. Vranken [13]; S. Jacobs [14]; F. Dedeurwaerdere12 [15]; G. Martens [16]; F. H. Devos [17]; F. P. Duhoux [18]; M. Rasschaert [19]; P. Pauwels [20]; K. Geboes [21]; J. Collignon20 [22]; S. Tejpar [23]; J.-L. Canon21 [24]; M. Peeters [25]; A. Rutten [26]; T. Van de Mooter23 [27]; J. Vermeij [28]; D. Schrijvers [29]; W. Demey [30]; W. Lybaert [31]; J. Van Huysse27 [32]; J. Mebis [33]; A. Awada [34]; K. B. M. Claes [35]; Aline Hébrant [36]; J. Van der Meulen [37]; B. Delafontaine30 [38]; I. Vanden Bempt [39]; J Maetens [40]; Maïté de Hemptinne [41]; S. Rottey [42]; P. Aftimos [43]; J. De Grève4 [44]

Keywords

  1. genomic alterations [45]
  2. genomic-driven therapy [46]
  3. metastatic tumors [47]
  4. molecular tumor board [48]
  5. Next-generation sequencing (NGS) [49]

Abstract:

PRECISION is an initiative from the Belgian Society of Medical Oncology (BSMO) in collaboration with several stakeholders, encompassing four programs that aim to boost genomic and clinical knowledge with the ultimate goal to offer patients with metastatic solid tumors molecularly guided treatments. The PRECISION 1 study has led to the creation of a clinicogenomic database. The Belgian Approach for Local Laboratory Extensive Tumor Testing (BALLETT) and GeNeo studies will increase the number of patients with advanced cancer that have comprehensive genotyping of their cancer. The PRECISION 2 p…
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Abstract

PRECISION is an initiative from the Belgian Society of Medical Oncology (BSMO) in collaboration with several stakeholders, encompassing four programs that aim to boost genomic and clinical knowledge with the ultimate goal to offer patients with metastatic solid tumors molecularly guided treatments. The PRECISION 1 study has led to the creation of a clinicogenomic database. The Belgian Approach for Local Laboratory Extensive Tumor Testing (BALLETT) and GeNeo studies will increase the number of patients with advanced cancer that have comprehensive genotyping of their cancer. The PRECISION 2 project consists of investigator-initiated phase II studies aiming to provide access to a targeted drug for patients whose tumors harbor actionable mutations in case the matched drug is not available through reimbursement or clinical trials in Belgium.

Associated health topics:


Source URL:https://www.sciensano.be/en/biblio/precision-belgian-molecular-profiling-program-metastatic-cancer-clinical-decision-and-treatment-0

Links
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