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A Refined Guinea Pig Model of Foot-and-Mouth Disease Virus Infection for Assessing the Efficacy of Antiviral Compounds.
Transbound Emerg Dis, Volume 63, Issue 2, p.e205-12 (2016) Keywords: Animals Antibodies, Viral Antiviral Agents Disease Models, Animal Europe Foot-and-Mouth Disease Foot-and-Mouth Disease Virus Guinea Pigs ...
Pseudorabies virus isolates from domestic pigs and wild boars show no apparent in vitro differences in replication kinetics and sensitivity to interferon-induced antiviral status.
Animals Antiviral Agents Cells, Cultured Herpesvirus 1, Suid Interferons Sus scrofa Viral Plaque Assay Virus Replication Abstract: Pseudorabies virus is the causative agent of Aujeszky’s disease. Domestic ...
The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.
Cameron, Craig E; Verdaguer, Nuria; Neyts, Johan; van Kuppeveld, Frank J M Source: PLoS Pathog, Volume 11, Issue 3, p.e1004733 (2015) Keywords: Animals Antiviral Agents Binding Sites Cardiovirus Chlorocebus ...
A thiazepino[4,5-a]benzimidazole derivative hampers the RNA replication of Eurasian serotypes of foot-and-mouth disease virus.
King, Donald P; Neyts, Johan; Kris De Clercq Source: Biochem Biophys Res Commun, Volume 455, Issue 3-4, p.378-81 (2014) Keywords: Animals Antiviral Agents Benzimidazoles Cell Line Cell Survival ...
Proof of concept for the inhibition of foot-and-mouth disease virus replication by the anti-viral drug 2'-C-methylcytidine in severe combined immunodeficient mice.
Dis, Volume 61, Issue 6, p.e89-91 (2014) Keywords: Animals Antiviral Agents Cytidine Disease Models, Animal Foot-and-Mouth Disease Foot-and-Mouth Disease Virus mice Mice, SCID RNA, Viral Abstract: Recent ...
Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase.
Neyts, Johan; Paeshuyse, Jan Source: Antiviral Res, Volume 106, p.71-9 (2014) Keywords: Animals Antiviral Agents Benzimidazoles Cattle Cell Line Classical swine fever virus Diarrhea Virus 1, Bovine Viral ...
In vitro surrogate models to aid in the development of antivirals for the containment of foot-and-mouth disease outbreaks.
Johan; Goris, Nesya Source: Antiviral Res, Volume 105, p.59-63 (2014) Keywords: Animals Antiviral Agents Aphthovirus Benzimidazoles Cattle Cell Line Chlorocebus aethiops Cytidine Cytopathogenic Effect, ...
Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.
Lefebvre, David; Lanke, Kjerstin H W; Kris De Clercq; Hilgenfeld, Rolf; Neyts, Johan; van Kuppeveld, Frank J M Source: Antiviral Res, Volume 103, p.17-24 (2014) Keywords: 3C Viral Proteases Animals Antiviral ...
Intra-host variation structure of classical swine fever virus NS5B in relation to antiviral therapy.
Substitution Animals Antiviral Agents Classical Swine Fever Classical swine fever virus Enzyme Inhibitors Genetic Variation Imidazoles Pyridines RNA Replicase Swine Viral Proteins Abstract: Classical swine fever ...
Development of a foot-and-mouth disease infection model in severe combined immunodeficient mice for the preliminary evaluation of antiviral drugs.
Publication Type: Peer reviewed scientific article Authors: David Lefebvre; Neyts, J; Kris De Clercq Source: Transbound Emerg Dis, Volume 57, Issue 6, p.430-3 (2010) Keywords: Animals Antiviral ...