Search results - 77 results
Time of drug administration, CYP3A5 and ABCB1 genotypes, and analytical method influence tacrolimus pharmacokinetics: a population pharmacokinetic study92
middle aged MODEL modeling Models,Biological ON P-Glycoprotein parameters Pharmacokinetic pharmacokinetics pharmacology POPULATION protein regression RENAL Renal Insufficiency result results Sample Samples ...
Establishment of the Ph. Eur. BRP for Varicella Vaccine Batch 1227
(Ph. Eur.) monograph for varicella vaccine (live) (0648) requires a vial of an appropriate reference material to be titred in triplicate to validate each assay and the virus concentration of the ...
Collaborative Study for the Validation of Alternative in vitro Potency Assays for Human Tetanus Immunoglobulin
vivo assay to be performed to determine the potency of human tetanus immunoglobulins during their development. Furthermore, it states that an in vitro method shall be validated for the batch potency ...
Establishment of the Ph. Eur. BRP for varicella vaccine batch 1.
monograph for varicella vaccine (live) (0648) requires a vial of an appropriate reference material to be titred in triplicate to validate each assay and the virus concentration of the reference preparation is ...
Validation of a liquid chromatography-mass spectrometric assay for tacrolimus in peripheral blood mononuclear cells.
peripheral blood mononuclear cell population (PBMC s). These cells, expected to be a more specific biological matrix than whole blood to reflect pharmacological efficacy, could be promising for TAC therapeutic ...
Establishment of Replacement Batches for Prekallikrein Activator in Albumin Biological Reference Preparation
current Prekallikrein activator in albumin Biological Reference Preparation (BRP) batch 1, the stocks of which were dwindling. Candidate BRP replacement batch 2 and batch 3 were assayed against the 2nd ...
Synthesis and biological activity of endomorphin-2 analogs incorporating piperidine-2-, 3- or 4-carboxylic acids instead of proline in position 24391
0.01 nM in comparison with IC (50) = 0.69 +/- 0.03 nM for EM-2. This analog was also very potent in the aequorin luminescence-based functional calcium assay and showed significantly enhanced stability in ...
Occurrence and genetic diversity of Bacillus anthracis strains isolated in an active wool-cleaning factory.
this cluster, five closely related VNTR subtypes could be identified, of which two were previously unreported. Additional diversity was observed when more sensitive genetic markers were assayed ...
Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure4392
the mu-opioid receptor and thus represent a potential framework for modification into mu-antagonists. Here we report on the synthesis and biological evaluation of novel [d-2-Nal(4)]endomorphin-2 ...
Bluetongue virus detection by two real-time RT-qPCRs targeting two different genomic segments.
sheep and cattle were negative. The two assays resulted in similar C(t) values when testing biological samples collected in sheep infected experimentally with a field strain of BTV from the Mediterranean ...