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Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo

composed of small or large agglomerates with similar dispersion medium composition. For in vitro testing, human bronchial epithelial (HBE), colon epithelial (Caco2) and monocytic (THP-1) cell lines were ...

Is aggregated synthetic amorphous silica toxicologically relevant?

stronger effects in all the cell lines than the aggregated suspension (AGGR). We then compared DE- AGGR with 2 suspensions fractionated from AGGR: the precipitated fraction (PREC) and the supernatant ...

In vitro 50 Hz magnetic field long-term exposure: Cytogenetic tests on human lymphoblastoid TK6 cells and validation of the test environment

In this manuscript, an optimized protocol for a combined in vitro comet/micronucleus study to investigate these effects in a human lymphoblastoid cell line (TK6) is provided including the description ...

Assessing the endocrine activity of PAHs using the DRE-, ERE- and PPARγ CALUX bioassays

human PPAR y2. 2) DRE- CALUX (dioxin responsive element) uses a third H1L7.5c1 generation cell line, derived from the mouse hepatoma hepa1c1c7 wild‐type cells, which contain the AhR receptor and 3) The ...

Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation.

target inhibition. The activity of isoniazid (INH), a key first-line bactericidal antituberculosis drug currently known to inhibit mycolic acid synthesis, becomes extremely poor under stress conditions, ...

RNA-based drug susceptibility testing of Mycobacterium tuberculosis

the knowledge on resistance mutations which is limited for especially 2nd-line and new drugs, (b) do not distinguish living from death cells, (c) ignore all intrinsic resistance mechanisms like efflux ...

Y-box-binding protein 1 supports the early and late steps of HIV replication.

HIV replication. YB-1 depletion resulted in a 10-fold decrease in HIV-1 replication in different cell lines. Dissection of the replication defects revealed that knockdown of YB-1 is associated with a 2- ...

Porcine NK Cells Stimulate Proliferation of Pseudorabies Virus-Experienced CD8 and CD4CD8 T Cells.

are particularly important in the first line defense against herpesviruses, including alphaherpesviruses. In addition to their ability to kill target cells and produce interferon-γ, porcine and human NK ...

A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment

for pharmaceutical, chemical, and consumer products, as afflicted compounds have to be (prematurely) abandoned or further tested on animals. Using the metabolically competent human HepaRG ™ cell line and toxicogenomics ...

Strain- and Dose-Dependent Reduction of Toxoplasma gondii Burden in Pigs Is Associated with Interferon-Gamma Production by CD8(+) Lymphocytes in a Heterologous Challenge Model.

Publication Type: Peer reviewed scientific article Authors: Jennes, Malgorzata; Stéphane De Craeye; Devriendt, Bert; Katelijne Dierick; Dorny, Pierre; Cox, Eric Source: Front Cell Infect Microbiol, ...

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