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RNA-based drug susceptibility testing of Mycobacterium tuberculosis

the knowledge on resistance mutations which is limited for especially 2nd-line and new drugs, (b) do not distinguish living from death cells, (c) ignore all intrinsic resistance mechanisms like efflux ...

Anti-mycobacterial activity of 1,3-diaryltriazenes.

Polanc, Slovenko; Huygen, Kris; Košmrlj, Janez Source: Eur J Med Chem, Volume 77, p.193-203 (2014) Keywords: Animals Antitubercular Agents Cell Line Cell Survival Dose-Response Relationship, Drug ...

Biological evaluation of diazene derivatives as anti-tubercular compounds.

examined for acute cell toxicity on a murine macrophage like monocyte cell line J774 A.1 in which the cell viability was reduced by 50% at concentrations ranging from 7.4 μg/mL to 20.7 μg/mL. Neither of the ...

Biological evaluation of bisbenzaldehydes against four Mycobacterium species.

Eynde, Jean Jacques; Huygen, Kris Source: Eur J Med Chem, Volume 63, p.731-8 (2013) Keywords: Animals Anti-Bacterial Agents Antitubercular Agents Benzaldehydes Cell Line Cell Survival Cells, Cultured ...

Critical aspects in implementing the OECD monograph No. 14 "the application of the principles of GLP to in vitro studies".

sometimes dysfunctioning because there is a lack of traceability in reporting and communication lines. Manipulation of cell and tissue cultures of different test systems should be separated and performed ...

The caspase-generated fragments of PKR cooperate to activate full-length PKR and inhibit translation.

Issue 5, p.1050-9 (2007) Keywords: Apoptosis Caspase Inhibitors caspases Cell Line eIF-2 Kinase Enzyme Activation Enzyme Inhibitors Humans Immunoprecipitation Jurkat Cells Necrosis Peptide Fragments ...

Characterization of the culture filtrate-specific cytotoxic T lymphocyte response induced by Bacillus Calmette-Guérin vaccination in H-2b mice.

CD8-Positive T-Lymphocytes Cell Line Chloroquine Culture Media H-2 Antigens Interferon-gamma Lymphocyte Activation Membrane Glycoproteins mice Mice, Inbred C57BL Perforin Pore Forming Cytotoxic Proteins ...

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