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Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation.

inhibition. The activity of isoniazid (INH), a key first-line bactericidal antituberculosis drug currently known to inhibit mycolic acid synthesis, becomes extremely poor under stress conditions, such as ...

Anti-mycobacterial activity of 1,3-diaryltriazenes.

Polanc, Slovenko; Huygen, Kris; Košmrlj, Janez Source: Eur J Med Chem, Volume 77, p.193-203 (2014) Keywords: Animals Antitubercular Agents Cell Line Cell Survival Dose-Response Relationship, Drug ...

Biological evaluation of diazene derivatives as anti-tubercular compounds.

examined for acute cell toxicity on a murine macrophage like monocyte cell line J774 A.1 in which the cell viability was reduced by 50% at concentrations ranging from 7.4 μg/mL to 20.7 μg/mL. Neither of the ...

Biological evaluation of bisbenzaldehydes against four Mycobacterium species.

Vanden Eynde, Jean Jacques; Huygen, Kris Source: Eur J Med Chem, Volume 63, p.731-8 (2013) Keywords: Animals Anti-Bacterial Agents Antitubercular Agents Benzaldehydes Cell Line Cell Survival Cells ...

Characterization of new Alternaria alternata-specific rat monoclonal antibodies

2-3, Number 162, p.151- 162 (2012) Keywords: Alternaria alternata Dwellings ELISA Monoclonal antibodies mould Abstract: In this study, three different rat hybridoma cell lines secreting monoclonal ...

Molecular mechanisms for the persistent bronchodilatory effect of the beta 2-adrenoceptor agonist salmeterol.

Agonists Adrenergic beta-Agonists Albuterol Bronchodilator Agents Cell Line Humans Models, Biological Protein Binding Receptor, Cannabinoid, CB1 Receptors, Adrenergic, beta-2 Salmeterol Xinafoate Abstract: ...

Critical aspects in implementing the OECD monograph No. 14 "the application of the principles of GLP to in vitro studies".

sometimes dysfunctioning because there is a lack of traceability in reporting and communication lines. Manipulation of cell and tissue cultures of different test systems should be separated and performed ...

The caspase-generated fragments of PKR cooperate to activate full-length PKR and inhibit translation.

Issue 5, p.1050-9 (2007) Keywords: Apoptosis Caspase Inhibitors caspases Cell Line eIF-2 Kinase Enzyme Activation Enzyme Inhibitors Humans Immunoprecipitation Jurkat Cells Necrosis Peptide Fragments ...

Characterization of the culture filtrate-specific cytotoxic T lymphocyte response induced by Bacillus Calmette-Guérin vaccination in H-2b mice.

CD8-Positive T-Lymphocytes Cell Line Chloroquine Culture Media H-2 Antigens Interferon-gamma Lymphocyte Activation Membrane Glycoproteins mice Mice, Inbred C57BL Perforin Pore Forming Cytotoxic Proteins ...

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