Search results - 20 results

A Transcriptomic Biomarker to Classify Chemical-Induced Histone Deacetylase Inhibition in Human HepaRGTM Cells

Science Forum, Ottawa, Canada (2024) Keywords: HepaRG cells histone deacetylase inhibition transcriptomic biomarker Health Topics:  Health and environment Santé et environnement Gezondheid en milieu ...

Pyrogen testing of phage therapeutic products

contamination (e.g. cell wall debris) is a major safety concern as these pro-inflammatory agents can cause unwanted clinical reactions with potential detrimental outcome. The most common and potent pyrogens are ...

The GENOMARK transcriptomic biomarker demonstrates a high predictivity for genotoxic hazards and utility in potency ranking in human HepaRGTM cells

Publication Type: Scientific poster, presentation or proceeding Authors: Anouck Thienpont; Eunnara Cho; Andrew Williams; Matthew Meier; Carole Yauk; Vera Rogiers; Tamara Vanhaecke; Birgit Mertens Source: EEMGS meeting, Malaga, Spain (2023) Keywords: bench ...

The GENOMARK biomarker inhuman HepaRGTM cells: a new approach methodology for genotoxicity assessment

Publication Type: Scientific poster, presentation or proceeding Authors: Anouck Thienpont; Stefaan Verhulst; Leo van Grunsven; Vera Rogiers; Tamara Vanhaecke; Birgit Mertens Source: SaferWorldByDesign webinar, Online (2023) Keywords: genotoxicity NAM tran ...

Assessing the endocrine activity of PAHs using the DRE-, ERE- and PPARγ CALUX bioassays

expression) bioassays were used to determine the endocrine activity: 1)The PPAR y CALUX ® system of BioDetection systems (BDS, Amsterdam) uses U‐ 2OS cells (human osteoblast) that are stably transfected with ...

RNA-based drug susceptibility testing of Mycobacterium tuberculosis

the knowledge on resistance mutations which is limited for especially 2nd-line and new drugs, (b) do not distinguish living from death cells, (c) ignore all intrinsic resistance mechanisms like efflux ...

Introducing speciation changes, human bioaccessibility and bioavailability in the risk evaluation of dietary inorganic arsenic intake: a Belgian case study

food matrices were obtained by means of the Caco-2 cell system. From these data, human intestinal absorption values were derived (bioavailability). To perform As in- and uptake calculations, different ...

Biological activity conferred by endocrine disrupting chemicals in hospital effluent and river water from the Brussels Region, Belgium

gene expression) bioassay using a luciferase reporter gene as part of BG1 luc4E2 cells (human ovarian adenocarcinoma). Responses are time, dose, and ligand specific using 17β-estradiol (the natural ...

Impact of MALT1, an upstream mediator of NF-kB and immune cell activation, on rabies virus disease.

Issue XX (2015) Keywords: Activation an Cell conference disease Impact ON Rabies Rabies virus VIRUS Service:  Virale ziekten Viral diseases Maladies virales Category:  C32 ...

On the alleged association between extremely low frequency magnetic field exposure and an increased risk of Alzheimer's disease

Various Fields of Research,, RAD Association, Issue RAD Association, Niš, Serbia, Number 154, Budva, Montenegro (2015) Keywords: Alzheimer’s disease C3A cells cytome assay magnetic fields SH-SY5T cells ...

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