Search results - 15 results

Shifting national surveillance of Shigella infections toward geno-serotyping by the development of a tailored Luminex assay and NGS workflow.

specificity of 96.6% and 98.4%, respectively. All discrepancies were analyzed with whole-genome sequencing and shown to be related to causative mutations (stop codons, indels, and promoter mutations) in ...

Attenuation of RNA viruses by redirecting their evolution in sequence space.

Neutralizing Antibodies, Viral Codon Codon, Nonsense Coxsackievirus Infections Disease Models, Animal Dogs Enterovirus B, Human HEK293 Cells HeLa Cells Humans Influenza A Virus, H1N1 Subtype Madin Darby Canine ...

Increased B and T Cell Responses in M. bovis Bacille Calmette-Guerin Vaccinated Pigs Co-Immunized with Plasmid DNA Encoding a Prototype Tuberculosis Antigen

primed with BCG mixed with empty vector or codon-optimized pAg85A by the intradermal route and boosted with plasmid delivered by intramuscular electroporation. Control pigs received unformulated BCG. The ...

The TREAT-NMD DMD Global Database: analysis of more than 7,000 Duchenne muscular dystrophy mutations

codon read-through therapies (10% of total mutations) and exon skipping therapy (80% of deletions and 55% of total mutations) Health Topics:  Neuromuscular diseases Maladies neuromusculaires ...

Trends in genotype frequency resulting from breeding for resistance to classical scrapie in Belgium (2006 ˜ 2011).

Female Genetic Predisposition to Disease Genetic Variation Genotype Male Scrapie Sheep Abstract: In sheep, susceptibility to scrapie is mainly determined by codons 136, 154, and 171 of the PRNP gene. Five ...

What's in a strain? Viral metagenomics identifies genetic variation and contaminating circoviruses in laboratory isolates of pigeon paramyxovirus type 1.

deep sequence data allowed identification of sequence variability in multiple PPMV-1 isolates, including one STOP codon in the Matrix gene which was present in 15% of the viral population of one isolate. ...

Salmonella typhi in the democratic republic of the congo: fluoroquinolone decreased susceptibility on the rise

and 1.0%, respectively. DCS was associated with point mutations in the gyrA gene at codons 83 and 87. CONCLUSIONS / SIGNIFICANCE: Our study describes the first report of widespread multidrug resistance ...

Overlapping signals for translational regulation and packaging of influenza A virus segment 2.

conclude that segment 2 mRNA translation is regulated by a combination of leaky ribosomal scanning and reinitiation, and that the sequences surrounding the PB1 AUG codon are multifunctional, containing ...

Development of a pyrosequencing assay for rapid assessment of quinolone resistance in Acinetobacter baumannii isolates36532

quinolone-resistance determining regions. A strong correlation was found between quinolone resistance and mutations in gyrA codon 83 and/or in the parC gene (codons 80 or 84). Absence of QRDR mutations was associated ...

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