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Partial reconstitution of the CD4+-T-cell compartment in CD4 gene knockout mice restores responses to tuberculosis DNA vaccines.
Publication Type: Peer reviewed scientific article Authors: D'Souza, Sushila; Marta Romano; Korf, Johanna; Wang, Xiao-Ming; Adnet, Pierre-Yves; Huygen, Kris Source: Infect Immun, Volume 74, ...
Priming but not boosting with plasmid DNA encoding mycolyl-transferase Ag85A from Mycobacterium tuberculosis increases the survival time of Mycobacterium bovis BCG vaccinated mice against low dose intravenous challenge with M. tuberculosis H37Rv.
Publication Type: Peer reviewed scientific article Authors: Marta Romano; D'Souza, Sushila; Adnet, Pierre-Yves; Laali, Rachid; Fabienne Jurion; Palfliet, Kamiel; Huygen, Kris Source: Vaccine, ...
Induction of in vivo functional Db-restricted cytolytic T cell activity against a putative phosphate transport receptor of Mycobacterium tuberculosis.
Publication Type: Peer reviewed scientific article Authors: Marta Romano; Olivier J Denis; D'Souza, Sushila; Wang, Xiao-Ming; Ottenhoff, Tom H M; Brulet, Jean-Marc; Huygen, Kris Source: ...
Mapping of murine Th1 helper T-Cell epitopes of mycolyl transferases Ag85A, Ag85B, and Ag85C from Mycobacterium tuberculosis.
Publication Type: Peer reviewed scientific article Authors: D'Souza, S; Rosseels, V; Romano, M; Tanghe, A; Denis, O; Fabienne Jurion; Castiglione, N; Vanonckelen, A; Palfliet, K; Huygen, Kris ...
Improved tuberculosis DNA vaccines by formulation in cationic lipids.
Publication Type: Peer reviewed scientific article Authors: D'Souza, S; Rosseels, V; Denis, O; Tanghe, A; De Smet, N; Fabienne Jurion; Palfliet, K; Castiglioni, N; Vanonckelen, A; Wheeler, C; ...
Culture filtrate specific H-2(b) restricted CD8+ T cells activated in vivo by Mycobacterium tuberculosis or bovis BCG recognize a restricted number of immunodominant peptides.
Publication Type: Peer reviewed scientific article Authors: Denis, Olivier; Stroobant, Vincent; Colau, Didier; D'Souza, Sushila; Huygen, Kris Source: Immunol Lett, Volume 81, Issue 2, p.115-24 ...
Improved immunogenicity and protective efficacy of a tuberculosis DNA vaccine encoding Ag85 by protein boosting.
Publication Type: Peer reviewed scientific article Authors: Tanghe, A; D'Souza, S; Rosseels, V; Denis, O; Ottenhoff, T H; Dalemans, W; Wheeler, C; Huygen, K Source: Infect Immun, Volume 69, ...
CD4+ T cells contain Mycobacterium tuberculosis infection in the absence of CD8+ T cells in mice vaccinated with DNA encoding Ag85A.
Publication Type: Peer reviewed scientific article Authors: D'Souza, S; Denis, O; Scorza, T; Nzabintwali, F; Verschueren, H; Huygen, K Source: Eur J Immunol, Volume 30, Issue 9, Number 2459, ...
Lack of protection in mice and necrotizing bronchointerstitial pneumonia with bronchiolitis in guinea pigs immunized with vaccines directed against the hsp60 molecule of Mycobacterium tuberculosis.
Publication Type: Peer reviewed scientific article Authors: Turner, O C; Roberts, A D; Frank, A A; Phalen, S W; McMurray, D M; Content, J; Denis, O; D'Souza, S; Tanghe, A; Huygen, K; Orme, ...
Immunogenicity and protective efficacy of DNA vaccines encoding secreted and non-secreted forms of Mycobacterium tuberculosis Ag85A.
Publication Type: Peer reviewed scientific article Authors: Baldwin, S L; D'Souza, C D; Orme, I M; Liu, M A; Huygen, K; Denis, O; Tang, A; Zhu, L; Montgomery, D; Ulmer, J B Source: Tuber Lung ...